T. Holtschke, et.al., Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene., Cell, 1996, 87

http://rdf.ncbi.nlm.nih.gov/pubmed/8861914

T. Holtschke, et.al., Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene., Cell, 1996, 87

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD15581
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD15581

allele

http://purl.org/net/cito/citesAsAuthority

• Irf8<tm1Hor>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1926332

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased leukocyte cell number_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0000218EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• enlarged liver_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0000599EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• increased sensitivity to induced morbidity/mortality_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0009763EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• increased immunoglobulin level_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0002461EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• enlarged lymph nodes_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0000702EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• increased lymphocyte cell number_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0005013EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• increased susceptibility to viral infection_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0002418EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• increased chronic myelocytic leukemia incidence_Irf8<tm1Hor>/Irf8<+>
  http://metadb.riken.jp/0005481EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8Irf8Irf8tm1Hor
• enlarged spleen_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0000691EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• increased B cell number_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0005014EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• abnormal megakaryocyte morphology_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0002417EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• decreased T cell number_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0005018EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• premature death_Irf8<tm1Hor>/Irf8<+>
  http://metadb.riken.jp/0002083EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8Irf8Irf8tm1Hor
• increased bone marrow cell number_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0000321EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• increased mature B cell number_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0008210EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• decreased B cell number_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0005017EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• decreased interferon-gamma secretion_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0008567EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• increased chronic myelocytic leukemia incidence_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0005481EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• increased spleen red pulp amount_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0008476EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• increased macrophage cell number_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0005425EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• premature death_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0002083EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• abnormal plasma cell number_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0008096EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• abnormal erythropoiesis_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0000245EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• abnormal cytotoxic T cell physiology_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0005078EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• abnormal definitive hematopoiesis_Irf8<tm1Hor>/Irf8<+>
  http://metadb.riken.jp/0002123EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8Irf8Irf8tm1Hor
• increased lymphoma incidence_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0012431EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• increased granulocyte number_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0000322EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• spleen hyperplasia_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0000693EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor
• decreased lymphocyte cell number_Irf8<tm1Hor>/Irf8<tm1Hor>
  http://metadb.riken.jp/0005016EI129P2OlaHsdorI129P2OlaHsdC57BL6Irf8tm1HorIrf8tm1HorIrf8tm1Hor