increased bone mineral density_Lrp5<tm1Grw>/Lrp5<tm1Grw>,Sost<tm1Paz>/Sost<tm1Paz>

http://metadb.riken.jp/0000062I129S1Sv129X1SvJBlackSwissLrp5tm1GrwLrp5tm1GrwSosttm1PazSosttm1PazLrp5tm1GrwSosttm1Paz

increased bone mineral density_Lrp5<tm1Grw>/Lrp5<tm1Grw>,Sost<tm1Paz>/Sost<tm1Paz>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• low density lipoprotein receptor-related protein 5
  http://metadb.riken.jp/db/mgi_rdf/MGI:1278315
• sclerostin
  http://metadb.riken.jp/db/mgi_rdf/MGI:1921749

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lrp5<tm1Grw>/Lrp5<tm1Grw>,Sost<tm1Paz>/Sost<tm1Paz>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lrp5<tm1Grw>|Sost<tm1Paz>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * Black Swiss

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased bone mineral density
  http://purl.obolibrary.org/obo/MP_0000062

文献

http://purl.org/net/cito/citesAsAuthority

• Rajendra. Kedlaya, et.al., Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome., Science translational medicine, 2013, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/24225945