Rajendra. Kedlaya, et.al., Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome., Science translational medicine, 2013, 5

http://rdf.ncbi.nlm.nih.gov/pubmed/24225945

Rajendra. Kedlaya, et.al., Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome., Science translational medicine, 2013, 5

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased trabecular bone mass_Lrp5<tm1Grw>/Lrp5<tm1Grw>,Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0010872I129S1Sv129X1SvJBlackSwissLrp5tm1GrwLrp5tm1GrwSosttm1PazSosttm1PazLrp5tm1GrwSosttm1Paz
• decreased bone stiffness_Lrp5<tm1Grw>/Lrp5<tm1Grw>
  http://metadb.riken.jp/0013639I129S1Sv129X1SvJLrp5tm1GrwLrp5tm1GrwLrp5tm1Grw
• increased bone volume_Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0010875I129SvBlackSwissSosttm1PazSosttm1PazSosttm1Paz
• increased bone stiffness_Lrp5<tm1Grw>/Lrp5<tm1Grw>,Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0013640I129S1Sv129X1SvJBlackSwissLrp5tm1GrwLrp5tm1GrwSosttm1PazSosttm1PazLrp5tm1GrwSosttm1Paz
• increased compact bone mass_Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0010961I129SvBlackSwissSosttm1PazSosttm1PazSosttm1Paz
• increased bone mineral density_Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0000062I129SvBlackSwissSosttm1PazSosttm1PazSosttm1Paz
• decreased bone mineral density_Lrp5<tm1Grw>/Lrp5<tm1Grw>
  http://metadb.riken.jp/0000063I129S1Sv129X1SvJLrp5tm1GrwLrp5tm1GrwLrp5tm1Grw
• decreased bone mass_Lrp5<tm1Grw>/Lrp5<tm1Grw>
  http://metadb.riken.jp/0004016I129S1Sv129X1SvJLrp5tm1GrwLrp5tm1GrwLrp5tm1Grw
• decreased bone strength_Lrp5<tm1Grw>/Lrp5<tm1Grw>
  http://metadb.riken.jp/0004991I129S1Sv129X1SvJLrp5tm1GrwLrp5tm1GrwLrp5tm1Grw
• increased bone strength_Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0004149I129SvBlackSwissSosttm1PazSosttm1PazSosttm1Paz
• abnormal bone mineralization_Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0002896I129SvBlackSwissSosttm1PazSosttm1PazSosttm1Paz
• increased bone mass_Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0005605I129SvBlackSwissSosttm1PazSosttm1PazSosttm1Paz
• decreased bone volume_Lrp5<tm1Grw>/Lrp5<tm1Grw>
  http://metadb.riken.jp/0010876I129S1Sv129X1SvJLrp5tm1GrwLrp5tm1GrwLrp5tm1Grw
• decreased bone mineralization_Lrp5<tm1Grw>/Lrp5<tm1Grw>
  http://metadb.riken.jp/0020137I129S1Sv129X1SvJLrp5tm1GrwLrp5tm1GrwLrp5tm1Grw
• decreased trabecular bone mass_Lrp5<tm1Grw>/Lrp5<tm1Grw>
  http://metadb.riken.jp/0010873I129S1Sv129X1SvJLrp5tm1GrwLrp5tm1GrwLrp5tm1Grw
• decreased bone mineral content_Lrp5<tm1Grw>/Lrp5<tm1Grw>
  http://metadb.riken.jp/0010124I129S1Sv129X1SvJLrp5tm1GrwLrp5tm1GrwLrp5tm1Grw
• increased bone mineral density_Lrp5<tm1Grw>/Lrp5<tm1Grw>,Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0000062I129S1Sv129X1SvJBlackSwissLrp5tm1GrwLrp5tm1GrwSosttm1PazSosttm1PazLrp5tm1GrwSosttm1Paz
• increased trabecular bone mass_Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0010872I129SvBlackSwissSosttm1PazSosttm1PazSosttm1Paz
• increased bone mineral content_Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0010123I129SvBlackSwissSosttm1PazSosttm1PazSosttm1Paz
• increased bone strength_Lrp5<tm1Grw>/Lrp5<tm1Grw>,Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0004149I129S1Sv129X1SvJBlackSwissLrp5tm1GrwLrp5tm1GrwSosttm1PazSosttm1PazLrp5tm1GrwSosttm1Paz
• increased bone stiffness_Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0013640I129SvBlackSwissSosttm1PazSosttm1PazSosttm1Paz
• increased bone mineral content_Lrp5<tm1Grw>/Lrp5<tm1Grw>,Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0010123I129S1Sv129X1SvJBlackSwissLrp5tm1GrwLrp5tm1GrwSosttm1PazSosttm1PazLrp5tm1GrwSosttm1Paz
• increased compact bone mass_Lrp5<tm1Grw>/Lrp5<tm1Grw>,Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0010961I129S1Sv129X1SvJBlackSwissLrp5tm1GrwLrp5tm1GrwSosttm1PazSosttm1PazLrp5tm1GrwSosttm1Paz
• increased bone mass_Lrp5<tm1Grw>/Lrp5<tm1Grw>,Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0005605I129S1Sv129X1SvJBlackSwissLrp5tm1GrwLrp5tm1GrwSosttm1PazSosttm1PazLrp5tm1GrwSosttm1Paz
• decreased compact bone mass_Lrp5<tm1Grw>/Lrp5<tm1Grw>
  http://metadb.riken.jp/0010962I129S1Sv129X1SvJLrp5tm1GrwLrp5tm1GrwLrp5tm1Grw
• osteoporosis_Lrp5<tm1Grw>/Lrp5<tm1Grw>
  http://metadb.riken.jp/0000066I129S1Sv129X1SvJLrp5tm1GrwLrp5tm1GrwLrp5tm1Grw
• increased bone volume_Lrp5<tm1Grw>/Lrp5<tm1Grw>,Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0010875I129S1Sv129X1SvJBlackSwissLrp5tm1GrwLrp5tm1GrwSosttm1PazSosttm1PazLrp5tm1GrwSosttm1Paz
• increased bone trabecula number_Lrp5<tm1Grw>/Lrp5<tm1Grw>,Sost<tm1Paz>/Sost<tm1Paz>
  http://metadb.riken.jp/0010868I129S1Sv129X1SvJBlackSwissLrp5tm1GrwLrp5tm1GrwSosttm1PazSosttm1PazLrp5tm1GrwSosttm1Paz