abnormal megakaryocyte differentiation_Itga2b<tm1(GFP/cre)Emam>/Itga2b<tm1(GFP/cre)Emam>,Rhoa<tm1Csab>/Rhoa<tm1Csab>,Tg(ITGA2B)3Mako/0,Tg(Pf4-icre)Q3Rsko/0

http://metadb.riken.jp/0000229I129S6SvEvTacC57BL6Itga2btm1GFPcreEmamItga2btm1GFPcreEmamRhoatm1CsabRhoatm1CsabTgITGA2B3Mako0TgPf4icreQ3Rsko0TgITGA2B3MakoRhoatm1CsabItga2btm1GFPcreEmamTgPf4icreQ3Rsko

abnormal megakaryocyte differentiation_Itga2b<tm1(GFP/cre)Emam>/Itga2b<tm1(GFP/cre)Emam>,Rhoa<tm1Csab>/Rhoa<tm1Csab>,Tg(ITGA2B)3Mako/0,Tg(Pf4-icre)Q3Rsko/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• ras homolog family member A
  http://metadb.riken.jp/db/mgi_rdf/MGI:1096342
• transgene insertion 3, Maria Anna Kowalska
  http://metadb.riken.jp/db/mgi_rdf/MGI:5548164
• integrin alpha 2b
  http://metadb.riken.jp/db/mgi_rdf/MGI:96601
• transgene insertion Q3, Radek C Skoda
  http://metadb.riken.jp/db/mgi_rdf/MGI:3764699

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Itga2b<tm1(GFP/cre)Emam>/Itga2b<tm1(GFP/cre)Emam>,Rhoa<tm1Csab>/Rhoa<tm1Csab>,Tg(ITGA2B)3Mako/0,Tg(Pf4-icre)Q3Rsko/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(ITGA2B)3Mako|Rhoa<tm1Csab>|Itga2b<tm1(GFP/cre)Emam>|Tg(Pf4-icre)Q3Rsko

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal megakaryocyte differentiation
  http://purl.obolibrary.org/obo/MP_0000229

文献

http://purl.org/net/cito/citesAsAuthority

• Aae. Suzuki, et.al., RhoA is essential for maintaining normal megakaryocyte ploidy and platelet generation., PloS one, 2013, 8
  http://rdf.ncbi.nlm.nih.gov/pubmed/23935982