heart right ventricle hypertrophy_Bmpr2<tm1Mmue>/Bmpr2<+>,Smad1<tm1Rjle>/Smad1<+>

http://metadb.riken.jp/0000276I129S1SvImJ129S6SvEvTacC57BL6Bmpr2tm1MmueBmpr2Smad1tm1RjleSmad1Smad1Bmpr2tm1MmueBmpr2Smad1tm1Rjle

heart right ventricle hypertrophy_Bmpr2<tm1Mmue>/Bmpr2<+>,Smad1<tm1Rjle>/Smad1<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• SMAD family member 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:109452
• bone morphogenetic protein receptor, type II (serine/threonine kinase)
  http://metadb.riken.jp/db/mgi_rdf/MGI:1095407

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Bmpr2<tm1Mmue>/Bmpr2<+>,Smad1<tm1Rjle>/Smad1<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Smad1<+>|Bmpr2<tm1Mmue>|Bmpr2<+>|Smad1<tm1Rjle>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• heart right ventricle hypertrophy
  http://purl.obolibrary.org/obo/MP_0000276

文献

http://purl.org/net/cito/citesAsAuthority

• Lu. Long, et.al., Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension., Nature medicine, 2015, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/26076038