Lu. Long, et.al., Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension., Nature medicine, 2015, 21

http://rdf.ncbi.nlm.nih.gov/pubmed/26076038

Lu. Long, et.al., Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension., Nature medicine, 2015, 21

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Bmpr2<tm1Mmue>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5776726

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• lethality, complete penetrance_Bmpr2<tm1Mmue>/Bmpr2<tm1Mmue>
  http://metadb.riken.jp/0011400B6129S1Bmpr2tm1MmueBmpr2tm1MmueBmpr2tm1MmueBmpr2tm1Mmue
• increased right ventricle systolic pressure_Bmpr2<tm1Mmue>/Bmpr2<+>,Smad1<tm1Rjle>/Smad1<+>
  http://metadb.riken.jp/0010758I129S1SvImJ129S6SvEvTacC57BL6Bmpr2tm1MmueBmpr2Smad1tm1RjleSmad1Smad1Bmpr2tm1MmueBmpr2Smad1tm1Rjle
• pulmonary hypertension_Bmpr2<tm1Mmue>/Bmpr2<+>
  http://metadb.riken.jp/0003548B6129S1Bmpr2tm1MmueBmpr2tm1MmueBmpr2Bmpr2tm1MmueBmpr2
• heart right ventricle hypertrophy_Bmpr2<tm1Mmue>/Bmpr2<+>,Smad1<tm1Rjle>/Smad1<+>
  http://metadb.riken.jp/0000276I129S1SvImJ129S6SvEvTacC57BL6Bmpr2tm1MmueBmpr2Smad1tm1RjleSmad1Smad1Bmpr2tm1MmueBmpr2Smad1tm1Rjle
• increased vascular permeability_Bmpr2<tm1Mmue>/Bmpr2<+>
  http://metadb.riken.jp/0003070B6129S1Bmpr2tm1MmueBmpr2tm1MmueBmpr2Bmpr2tm1MmueBmpr2
• abnormal pulmonary artery morphology_Bmpr2<tm1Mmue>/Bmpr2<+>
  http://metadb.riken.jp/0000484B6129S1Bmpr2tm1MmueBmpr2tm1MmueBmpr2Bmpr2tm1MmueBmpr2
• increased right ventricle systolic pressure_Bmpr2<tm1Mmue>/Bmpr2<+>
  http://metadb.riken.jp/0010758B6129S1Bmpr2tm1MmueBmpr2tm1MmueBmpr2Bmpr2tm1MmueBmpr2

class

http://purl.org/net/cito/citesAsAuthority

• Bmpr2<tm1Mmue>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5776726