abnormal atrioventricular cushion morphology_Hey1<tm1Kkb>/Hey1<tm1Kkb>,Mesp1<tm2(cre)Ysa>/Mesp1<+>,Tg(CAG-cat,-Notch1)1Ysa/0

http://metadb.riken.jp/0000297I129S7SvEvBrdC3HC57BL6CBAHey1tm1KkbHey1tm1KkbMesp1tm2creYsaMesp1TgCAGcatNotch11Ysa0Mesp1tm2creYsaTgCAGcatNotch11YsaHey1tm1KkbMesp1

abnormal atrioventricular cushion morphology_Hey1<tm1Kkb>/Hey1<tm1Kkb>,Mesp1<tm2(cre)Ysa>/Mesp1<+>,Tg(CAG-cat,-Notch1)1Ysa/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• hairy/enhancer-of-split related with YRPW motif 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1341800
• transgene insertion 1, Yumiko Saga
  http://metadb.riken.jp/db/mgi_rdf/MGI:3702437
• mesoderm posterior 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:107785

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Hey1<tm1Kkb>/Hey1<tm1Kkb>,Mesp1<tm2(cre)Ysa>/Mesp1<+>,Tg(CAG-cat,-Notch1)1Ysa/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mesp1<tm2(cre)Ysa>|Tg(CAG-cat,-Notch1)1Ysa|Hey1<tm1Kkb>|Mesp1<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd * C3H * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal atrioventricular cushion morphology
  http://purl.obolibrary.org/obo/MP_0000297

文献

http://purl.org/net/cito/citesAsAuthority

• Yusuke. Watanabe, et.al., Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse., Development (Cambridge, England), 2006, 133
  http://rdf.ncbi.nlm.nih.gov/pubmed/16554359