decreased bone marrow cell number_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>,Tg(Vav1-cre)1Graf/0

http://metadb.riken.jp/0000333I129S1SvC57BL6Dot1ltm11SaamDot1ltm11SaamTgVav1cre1Graf0TgVav1cre1GrafDot1ltm11Saam

decreased bone marrow cell number_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>,Tg(Vav1-cre)1Graf/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• DOT1-like, histone H3 methyltransferase (S. cerevisiae)
  http://metadb.riken.jp/db/mgi_rdf/MGI:2143886
• transgene insertion 1, Thomas Graf
  http://metadb.riken.jp/db/mgi_rdf/MGI:3765352

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>,Tg(Vav1-cre)1Graf/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Vav1-cre)1Graf|Dot1l<tm1.1Saam>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased bone marrow cell number
  http://purl.obolibrary.org/obo/MP_0000333

文献

http://purl.org/net/cito/citesAsAuthority

• Kathrin M. Bernt, et.al., MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L., Cancer cell, 2011, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/21741597