Kathrin M. Bernt, et.al., MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L., Cancer cell, 2011, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/21741597

Kathrin M. Bernt, et.al., MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L., Cancer cell, 2011, 20

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Dot1l<tm1.1Saam>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5468988

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased common myeloid progenitor cell number_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0008813I129S1SvC57BL6Dot1ltm11SaamDot1ltm11SaamTgVav1cre1Graf0TgVav1cre1GrafDot1ltm11Saam
• impaired hematopoiesis_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0001606I129S1SvC57BL6Dot1ltm11SaamDot1ltm11SaamTgVav1cre1Graf0TgVav1cre1GrafDot1ltm11Saam
• no abnormal phenotype detected_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>
  http://metadb.riken.jp/0002169I129S1SvC57BL6Dot1ltm11SaamDot1ltm11SaamDot1ltm11Saam
• abnormal definitive hematopoiesis_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0002123I129S1SvC57BL6Dot1ltm11SaamDot1ltm11SaamTgVav1cre1Graf0TgVav1cre1GrafDot1ltm11Saam
• decreased lymphocyte cell number_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0005016I129S1SvC57BL6Dot1ltm11SaamDot1ltm11SaamTgVav1cre1Graf0TgVav1cre1GrafDot1ltm11Saam
• abnormal bone marrow cell morphology/development_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>
  http://metadb.riken.jp/0002398I129S1SvC57BL6Dot1ltm11SaamDot1ltm11SaamDot1ltm11Saam
• abnormal leukopoiesis_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0005460I129S1SvC57BL6Dot1ltm11SaamDot1ltm11SaamTgVav1cre1Graf0TgVav1cre1GrafDot1ltm11Saam
• decreased neutrophil cell number_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000222I129S1SvC57BL6Dot1ltm11SaamDot1ltm11SaamTgVav1cre1Graf0TgVav1cre1GrafDot1ltm11Saam
• abnormal bone marrow cell physiology_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>
  http://metadb.riken.jp/0009278I129S1SvC57BL6Dot1ltm11SaamDot1ltm11SaamDot1ltm11Saam
• decreased bone marrow cell number_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000333I129S1SvC57BL6Dot1ltm11SaamDot1ltm11SaamTgVav1cre1Graf0TgVav1cre1GrafDot1ltm11Saam
• decreased tumor growth/size_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>
  http://metadb.riken.jp/0003447I129S1SvC57BL6Dot1ltm11SaamDot1ltm11SaamDot1ltm11Saam
• decreased hematopoietic stem cell number_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0004810I129S1SvC57BL6Dot1ltm11SaamDot1ltm11SaamTgVav1cre1Graf0TgVav1cre1GrafDot1ltm11Saam
• anemia_Dot1l<tm1.1Saam>/Dot1l<tm1.1Saam>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0001577I129S1SvC57BL6Dot1ltm11SaamDot1ltm11SaamTgVav1cre1Graf0TgVav1cre1GrafDot1ltm11Saam

class

http://purl.org/net/cito/citesAsAuthority

• Dot1l<tm1.1Saam>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5468988