abnormal pulmonary artery morphology_Bmpr2<tm1.1Enl>/Bmpr2<tm1.1Enl>,Tg(Acvrl1-cre)L1Spo/0

http://metadb.riken.jp/0000484I129S4SvJaeFVBBmpr2tm11EnlBmpr2tm11EnlTgAcvrl1creL1Spo0TgAcvrl1creL1SpoBmpr2tm11Enl

abnormal pulmonary artery morphology_Bmpr2<tm1.1Enl>/Bmpr2<tm1.1Enl>,Tg(Acvrl1-cre)L1Spo/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion L1, S Paul Oh
  http://metadb.riken.jp/db/mgi_rdf/MGI:4398907
• bone morphogenetic protein receptor, type II (serine/threonine kinase)
  http://metadb.riken.jp/db/mgi_rdf/MGI:1095407

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Bmpr2<tm1.1Enl>/Bmpr2<tm1.1Enl>,Tg(Acvrl1-cre)L1Spo/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Acvrl1-cre)L1Spo|Bmpr2<tm1.1Enl>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * FVB

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal pulmonary artery morphology
  http://purl.obolibrary.org/obo/MP_0000484

文献

http://purl.org/net/cito/citesAsAuthority

• Kwon-Ho. Hong, et.al., Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension., Circulation, 2008, 118
  http://rdf.ncbi.nlm.nih.gov/pubmed/18663089