abnormal crypts of Lieberkuhn morphology_Col1a1<tm1(tetO-CTNNB1)Tcd>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>

http://metadb.riken.jp/0000490I129S4SvJaeC57BL6C57BL6JCol1a1tm1tetOCTNNB1TcdCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2JaeCol1a1tm1tetOCTNNB1Tcd

abnormal crypts of Lieberkuhn morphology_Col1a1<tm1(tetO-CTNNB1)Tcd>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• collagen, type I, alpha 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88467
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Col1a1<tm1(tetO-CTNNB1)Tcd>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<+>|Col1a1<+>|Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>|Col1a1<tm1(tetO-CTNNB1)Tcd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal crypts of Lieberkuhn morphology
  http://purl.obolibrary.org/obo/MP_0000490

文献

http://purl.org/net/cito/citesAsAuthority

• T. Jardé, et.al., In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system., Oncogene, 2013, 32
  http://rdf.ncbi.nlm.nih.gov/pubmed/22469981