T. Jardé, et.al., In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system., Oncogene, 2013, 32

http://rdf.ncbi.nlm.nih.gov/pubmed/22469981

T. Jardé, et.al., In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system., Oncogene, 2013, 32

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm1(tetO-CTNNB1)Tcd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5469323

class

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm1(tetO-CTNNB1)Tcd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5469323

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal crypts of Lieberkuhn morphology_Col1a1<tm1(tetO-CTNNB1)Tcd>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000490I129S4SvJaeC57BL6C57BL6JCol1a1tm1tetOCTNNB1TcdCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2JaeCol1a1tm1tetOCTNNB1Tcd
• decreased body weight_Col1a1<tm1(tetO-CTNNB1)Tcd>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001262I129S4SvJaeC57BL6C57BL6JCol1a1tm1tetOCTNNB1TcdCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2JaeCol1a1tm1tetOCTNNB1Tcd
• abnormal enterocyte proliferation_Col1a1<tm1(tetO-CTNNB1)Tcd>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008883I129S4SvJaeC57BL6C57BL6JCol1a1tm1tetOCTNNB1TcdCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2JaeCol1a1tm1tetOCTNNB1Tcd
• abnormal enterocyte apoptosis_Col1a1<tm1(tetO-CTNNB1)Tcd>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008884I129S4SvJaeC57BL6C57BL6JCol1a1tm1tetOCTNNB1TcdCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2JaeCol1a1tm1tetOCTNNB1Tcd
• increased enterocyte apoptosis_Col1a1<tm1(tetO-CTNNB1)Tcd>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008885I129S4SvJaeC57BL6C57BL6JCol1a1tm1tetOCTNNB1TcdCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2JaeCol1a1tm1tetOCTNNB1Tcd
• abnormal intestine development_Col1a1<tm1(tetO-CTNNB1)Tcd>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010158I129S4SvJaeC57BL6C57BL6JCol1a1tm1tetOCTNNB1TcdCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2JaeCol1a1tm1tetOCTNNB1Tcd