enlarged spleen_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>,Tg(BCL2)22Wehi/0

http://metadb.riken.jp/0000691I129S6SvEvTacC57BL6JWehiSJLJWehiGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aTgBCL222Wehi0GtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjumCd79atm3creERT2RethTgBCL222Wehi

enlarged spleen_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>,Tg(BCL2)22Wehi/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 22, Walter and Eliza Hall Institute of Medical Research
  http://metadb.riken.jp/db/mgi_rdf/MGI:3052829
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• CD79A antigen (immunoglobulin-associated alpha)
  http://metadb.riken.jp/db/mgi_rdf/MGI:101774

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>,Tg(BCL2)22Wehi/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<+>|Cd79a<+>|Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>|Cd79a<tm3(cre/ERT2)Reth>|Tg(BCL2)22Wehi

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6JWehi * SJL/JWehi

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• enlarged spleen
  http://purl.obolibrary.org/obo/MP_0000691

文献

http://purl.org/net/cito/citesAsAuthority

• E. Hug, et.al., Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation., Oncogene, 2014, 33
  http://rdf.ncbi.nlm.nih.gov/pubmed/23955076