E. Hug, et.al., Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation., Oncogene, 2014, 33

http://rdf.ncbi.nlm.nih.gov/pubmed/23955076

E. Hug, et.al., Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation., Oncogene, 2014, 33

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5568502

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal circulating chemokine level_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0010209I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• increased interleukin-10 secretion_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008660I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• enlarged lymph nodes_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0000702I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• enlarged spleen_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0000691I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• increased circulating interferon-gamma level_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008577I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• abnormal plasma cell differentiation_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008099I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• increased circulating interleukin-10 level_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008593I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• enlarged lymph nodes_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>,Tg(BCL2)22Wehi/0
  http://metadb.riken.jp/0000702I129S6SvEvTacC57BL6JWehiSJLJWehiGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aTgBCL222Wehi0GtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjumCd79atm3creERT2RethTgBCL222Wehi
• increased tumor necrosis factor secretion_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008560I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• increased circulating interleukin-6 level_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008596I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• abnormal B cell physiology_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>,Tg(BCL2)22Wehi/0
  http://metadb.riken.jp/0002459I129S6SvEvTacC57BL6JWehiSJLJWehiGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aTgBCL222Wehi0GtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjumCd79atm3creERT2RethTgBCL222Wehi
• increased IgM level_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0002494I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• increased B cell proliferation_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0005154I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• increased B cell apoptosis_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008782I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• abnormal plasma cell differentiation_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>,Tg(BCL2)22Wehi/0
  http://metadb.riken.jp/0008099I129S6SvEvTacC57BL6JWehiSJLJWehiGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aTgBCL222Wehi0GtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjumCd79atm3creERT2RethTgBCL222Wehi
• abnormal cytokine level_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008713I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• enlarged spleen_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>,Tg(BCL2)22Wehi/0
  http://metadb.riken.jp/0000691I129S6SvEvTacC57BL6JWehiSJLJWehiGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aTgBCL222Wehi0GtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjumCd79atm3creERT2RethTgBCL222Wehi
• increased B cell number_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0005014I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• increased interferon-gamma secretion_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008566I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• increased circulating tumor necrosis factor level_Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>/Gt(ROSA)26Sor<+>,Cd79a<tm3(cre/ERT2)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008553I129S6SvEvTacGtROSA26Sortm1ETV6SYKHjumGtROSA26SorCd79atm3creERT2RethCd79aCd79atm3creERT2RethGtROSA26SorCd79aGtROSA26Sortm1ETV6SYKHjum
• abnormal B cell morphology_Syk<tm1.2Tara>/Syk<tm1.2Tara>,Tg(Cr2-cre)3Cgn/0
  http://metadb.riken.jp/0004939I129P2OlaHsdSyktm12TaraSyktm12TaraTgCr2cre3Cgn0TgCr2cre3CgnSyktm12Tara

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5568502