decreased thymocyte number_Brca1<tm2Mak>/Brca1<tm2Mak>,Cdkn1a<tm1Tyj>/Cdkn1a<tm1Tyj>,Tg(Lck-cre)548Jxm/?

http://metadb.riken.jp/0000715I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakCdkn1atm1TyjCdkn1atm1TyjTgLckcre548JxmCdkn1atm1TyjTgLckcre548JxmBrca1tm2Mak

decreased thymocyte number_Brca1<tm2Mak>/Brca1<tm2Mak>,Cdkn1a<tm1Tyj>/Cdkn1a<tm1Tyj>,Tg(Lck-cre)548Jxm/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 548, Jamey Marth
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176198
• breast cancer 1, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:104537
• cyclin-dependent kinase inhibitor 1A (P21)
  http://metadb.riken.jp/db/mgi_rdf/MGI:104556

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca1<tm2Mak>/Brca1<tm2Mak>,Cdkn1a<tm1Tyj>/Cdkn1a<tm1Tyj>,Tg(Lck-cre)548Jxm/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cdkn1a<tm1Tyj>|Tg(Lck-cre)548Jxm|Brca1<tm2Mak>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased thymocyte number
  http://purl.obolibrary.org/obo/MP_0000715

文献

http://purl.org/net/cito/citesAsAuthority

• T W. Mak, et.al., Brca1 required for T cell lineage development but not TCR loci rearrangement., Nature immunology, 2000, 1
  http://rdf.ncbi.nlm.nih.gov/pubmed/10881179