T W. Mak, et.al., Brca1 required for T cell lineage development but not TCR loci rearrangement., Nature immunology, 2000, 1

http://rdf.ncbi.nlm.nih.gov/pubmed/10881179

T W. Mak, et.al., Brca1 required for T cell lineage development but not TCR loci rearrangement., Nature immunology, 2000, 1

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Brca1<tm2Mak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2429692

class

http://purl.org/net/cito/citesAsAuthority

• Brca1<tm2Mak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2429692

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased T cell proliferation_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?,Tg(TcrLCMV)327Sdz/?
  http://metadb.riken.jp/0005095I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmTgTcrLCMV327SdzTgLckcre548JxmBrca1tm2MakTgTcrLCMV327Sdz
• spontaneous chromosome breakage_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(BCL2)36Wehi/?,Tg(Lck-cre)548Jxm/?
  http://metadb.riken.jp/0004029I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgBCL236WehiTgLckcre548JxmBrca1tm2MakTgBCL236WehiTgLckcre548Jxm
• decreased single-positive T cell number_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?
  http://metadb.riken.jp/0008083I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmBrca1tm2MakTgLckcre548Jxm
• spontaneous chromosome breakage_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0004029I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmTrp53tm1BrdTrp53tm1BrdTgLckcre548JxmBrca1tm2MakTrp53tm1Brd
• abnormal cell death_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?
  http://metadb.riken.jp/0000313I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmBrca1tm2MakTgLckcre548Jxm
• increased double-negative T cell number_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?
  http://metadb.riken.jp/0005090I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmBrca1tm2MakTgLckcre548Jxm
• decreased thymocyte number_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?
  http://metadb.riken.jp/0000715I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmBrca1tm2MakTgLckcre548Jxm
• decreased double-positive T cell number_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?,Tg(TcrLCMV)327Sdz/?
  http://metadb.riken.jp/0005092I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmTgTcrLCMV327SdzTgLckcre548JxmBrca1tm2MakTgTcrLCMV327Sdz
• decreased double-positive T cell number_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?
  http://metadb.riken.jp/0005092I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmBrca1tm2MakTgLckcre548Jxm
• abnormal immune system organ morphology_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?
  http://metadb.riken.jp/0002722I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmBrca1tm2MakTgLckcre548Jxm
• abnormal cell cycle checkpoint function_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?
  http://metadb.riken.jp/0004045I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmBrca1tm2MakTgLckcre548Jxm
• abnormal T cell number_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?,Tg(TcrLCMV)327Sdz/?
  http://metadb.riken.jp/0006387I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmTgTcrLCMV327SdzTgLckcre548JxmBrca1tm2MakTgTcrLCMV327Sdz
• chromosomal instability_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(BCL2)36Wehi/?,Tg(Lck-cre)548Jxm/?
  http://metadb.riken.jp/0008866I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgBCL236WehiTgLckcre548JxmBrca1tm2MakTgBCL236WehiTgLckcre548Jxm
• abnormal T cell number_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?
  http://metadb.riken.jp/0006387I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmBrca1tm2MakTgLckcre548Jxm
• decreased thymocyte number_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?,Tg(TcrLCMV)327Sdz/?
  http://metadb.riken.jp/0000715I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmTgTcrLCMV327SdzTgLckcre548JxmBrca1tm2MakTgTcrLCMV327Sdz
• increased double-negative T cell number_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?,Tg(TcrLCMV)327Sdz/?
  http://metadb.riken.jp/0005090I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmTgTcrLCMV327SdzTgLckcre548JxmBrca1tm2MakTgTcrLCMV327Sdz
• decreased T cell proliferation_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?
  http://metadb.riken.jp/0005095I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmBrca1tm2MakTgLckcre548Jxm
• increased cellular sensitivity to gamma-irradiation_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?
  http://metadb.riken.jp/0002007I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmBrca1tm2MakTgLckcre548Jxm
• chromosomal instability_Brca1<tm2Mak>/Brca1<tm2Mak>,Tg(Lck-cre)548Jxm/?,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0008866I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakTgLckcre548JxmTrp53tm1BrdTrp53tm1BrdTgLckcre548JxmBrca1tm2MakTrp53tm1Brd
• decreased thymocyte number_Brca1<tm2Mak>/Brca1<tm2Mak>,Cdkn1a<tm1Tyj>/Cdkn1a<tm1Tyj>,Tg(Lck-cre)548Jxm/?
  http://metadb.riken.jp/0000715I129P2OlaHsdC57BL6CBABrca1tm2MakBrca1tm2MakCdkn1atm1TyjCdkn1atm1TyjTgLckcre548JxmCdkn1atm1TyjTgLckcre548JxmBrca1tm2Mak