hippocampal neuron degeneration_Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0,Tg(Prnp-MAPT*P301S)PS19Vle/0

http://metadb.riken.jp/0000811B6CgTgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19VleTgAPPSwFlLonPSEN1M146LL286V6799Vas0TgPrnpMAPTP301SPS19Vle0TgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19Vle

hippocampal neuron degeneration_Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0,Tg(Prnp-MAPT*P301S)PS19Vle/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion PS19, Virginia M Y Lee
  http://metadb.riken.jp/db/mgi_rdf/MGI:3768406
• transgene insertion 6799, Robert Vassar
  http://metadb.riken.jp/db/mgi_rdf/MGI:3693207

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0,Tg(Prnp-MAPT*P301S)PS19Vle/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas|Tg(Prnp-MAPT*P301S)PS19Vle

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas Tg(Prnp-MAPT*P301S)PS19Vle

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• hippocampal neuron degeneration
  http://purl.obolibrary.org/obo/MP_0000811

文献

http://purl.org/net/cito/citesAsAuthority

• Anika. Saul, et.al., Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease., Neurobiology of aging, 2013, 34
  http://rdf.ncbi.nlm.nih.gov/pubmed/23747045