Anika. Saul, et.al., Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease., Neurobiology of aging, 2013, 34

http://rdf.ncbi.nlm.nih.gov/pubmed/23747045

Anika. Saul, et.al., Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease., Neurobiology of aging, 2013, 34

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• loss of hippocampal neurons_Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0,Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0003240B6CgTgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19VleTgAPPSwFlLonPSEN1M146LL286V6799Vas0TgPrnpMAPTP301SPS19Vle0TgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19Vle
• abnormal hippocampus morphology_Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0,Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0000807B6CgTgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19VleTgAPPSwFlLonPSEN1M146LL286V6799Vas0TgPrnpMAPTP301SPS19Vle0TgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19Vle
• hippocampal neuron degeneration_Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0,Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0000811B6CgTgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19VleTgAPPSwFlLonPSEN1M146LL286V6799Vas0TgPrnpMAPTP301SPS19Vle0TgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19Vle
• amyloid beta deposits_Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0,Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0003329B6CgTgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19VleTgAPPSwFlLonPSEN1M146LL286V6799Vas0TgPrnpMAPTP301SPS19Vle0TgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19Vle
• hippocampus atrophy_Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0,Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0030003B6CgTgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19VleTgAPPSwFlLonPSEN1M146LL286V6799Vas0TgPrnpMAPTP301SPS19Vle0TgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19Vle
• abnormal dendrite morphology_Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0,Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0008143B6CgTgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19VleTgAPPSwFlLonPSEN1M146LL286V6799Vas0TgPrnpMAPTP301SPS19Vle0TgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19Vle
• astrocytosis_Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0,Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0003354B6CgTgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19VleTgAPPSwFlLonPSEN1M146LL286V6799Vas0TgPrnpMAPTP301SPS19Vle0TgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19Vle
• abnormal hippocampal mossy fiber morphology_Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0,Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0002761B6CgTgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19VleTgAPPSwFlLonPSEN1M146LL286V6799Vas0TgPrnpMAPTP301SPS19Vle0TgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19Vle
• abnormal synapse morphology_Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0,Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0009538B6CgTgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19VleTgAPPSwFlLonPSEN1M146LL286V6799Vas0TgPrnpMAPTP301SPS19Vle0TgAPPSwFlLonPSEN1M146LL286V6799VasTgPrnpMAPTP301SPS19Vle