Purkinje cell degeneration_Mfn1<tm1Dcc>/Mfn1<tm2Dcc>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0

http://metadb.riken.jp/0000876I129129S4SvJaeSorBlackSwissMfn1tm1DccMfn1tm2DccMfn2tm1DccMfn2tm3DccTgPcp2cre2Mpin0TgPcp2cre2MpinMfn2tm3DccMfn2tm1DccMfn1tm2DccMfn1tm1Dcc

Purkinje cell degeneration_Mfn1<tm1Dcc>/Mfn1<tm2Dcc>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• mitofusin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1914664
• transgene insertion 2, Max-Planck-Institute of Neurobiology
  http://metadb.riken.jp/db/mgi_rdf/MGI:2137514
• mitofusin 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:2442230

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mfn1<tm1Dcc>/Mfn1<tm2Dcc>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Pcp2-cre)2Mpin|Mfn2<tm3Dcc>|Mfn2<tm1Dcc>|Mfn1<tm2Dcc>|Mfn1<tm1Dcc>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * 129S4/SvJaeSor * Black Swiss

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• Purkinje cell degeneration
  http://purl.obolibrary.org/obo/MP_0000876

文献

http://purl.org/net/cito/citesAsAuthority

• Hsiuchen. Chen, et.al., Mitochondrial fusion protects against neurodegeneration in the cerebellum., Cell, 2007, 130
  http://rdf.ncbi.nlm.nih.gov/pubmed/17693261