Hsiuchen. Chen, et.al., Mitochondrial fusion protects against neurodegeneration in the cerebellum., Cell, 2007, 130

http://rdf.ncbi.nlm.nih.gov/pubmed/17693261

Hsiuchen. Chen, et.al., Mitochondrial fusion protects against neurodegeneration in the cerebellum., Cell, 2007, 130

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Mfn1<tm2Dcc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3779080
• Mfn2<tm3Dcc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3779081

class

http://purl.org/net/cito/citesAsAuthority

• Mfn1<tm2Dcc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3779080
• Mfn2<tm3Dcc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3779081

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased body size_Meox2<tm1(cre)Sor>/Meox2<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0001265I129SSvEv129S4SvJaeSorBlackSwissMeox2tm1creSorMeox2Mfn2tm1DccMfn2tm3DccMfn2tm3DccMeox2Meox2tm1creSorMfn2tm1Dcc
• no abnormal phenotype detected_Meox2<tm1(cre)Sor>/Meox2<+>,Mfn1<tm1Dcc>/Mfn1<tm2Dcc>
  http://metadb.riken.jp/0002169I129SSvEv129S4SvJaeSorBlackSwissMeox2tm1creSorMeox2Mfn1tm1DccMfn1tm2DccMeox2tm1creSorMfn1tm2DccMfn1tm1DccMeox2
• impaired righting response_En1<tm2(cre)Wrst>/En1<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0001523I129129S4SvJaeSorBlackSwissEn1tm2creWrstEn1Mfn2tm1DccMfn2tm3DccMfn2tm1DccEn1En1tm2creWrstMfn2tm3Dcc
• abnormal cerebellum morphology_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0
  http://metadb.riken.jp/0000849I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccTgPcp2cre2Mpin0Mfn2tm1DccTgPcp2cre2MpinMfn2tm3Dcc
• abnormal mitochondrion morphology_Mfn1<tm1Dcc>/Mfn1<tm2Dcc>
  http://metadb.riken.jp/0006035I129129S4SvJaeSorBlackSwissMfn1tm1DccMfn1tm2DccMfn1tm2DccMfn1tm1Dcc
• impaired limb coordination_Meox2<tm1(cre)Sor>/Meox2<+>,Mfn1<tm2Dcc>/Mfn1<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0001524I129SSvEv129S4SvJaeSorBlackSwissMeox2tm1creSorMeox2Mfn1tm2DccMfn1Mfn2tm1DccMfn2tm3DccMeox2tm1creSorMfn2tm1DccMfn1tm2DccMfn2tm3DccMfn1Meox2
• impaired righting response_Meox2<tm1(cre)Sor>/Meox2<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0001523I129SSvEv129S4SvJaeSorBlackSwissMeox2tm1creSorMeox2Mfn2tm1DccMfn2tm3DccMfn2tm3DccMeox2Meox2tm1creSorMfn2tm1Dcc
• abnormal Purkinje cell dendrite morphology_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0
  http://metadb.riken.jp/0008572I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccTgPcp2cre2Mpin0Mfn2tm1DccTgPcp2cre2MpinMfn2tm3Dcc
• decreased body size_En1<tm2(cre)Wrst>/En1<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0001265I129129S4SvJaeSorBlackSwissEn1tm2creWrstEn1Mfn2tm1DccMfn2tm3DccMfn2tm1DccEn1En1tm2creWrstMfn2tm3Dcc
• small cerebellum_Meox2<tm1(cre)Sor>/Meox2<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0000852I129SSvEv129S4SvJaeSorBlackSwissMeox2tm1creSorMeox2Mfn2tm1DccMfn2tm3DccMfn2tm3DccMeox2Meox2tm1creSorMfn2tm1Dcc
• impaired limb coordination_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0001524I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccTgWnt1cre11Rth0Mfn2tm3DccMfn2tm1DccTgWnt1cre11Rth
• decreased body size_Meox2<tm1(cre)Sor>/Meox2<+>,Mfn1<tm2Dcc>/Mfn1<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0001265I129SSvEv129S4SvJaeSorBlackSwissMeox2tm1creSorMeox2Mfn1tm2DccMfn1Mfn2tm1DccMfn2tm3DccMeox2tm1creSorMfn2tm1DccMfn1tm2DccMfn2tm3DccMfn1Meox2
• Purkinje cell degeneration_Mfn1<tm1Dcc>/Mfn1<tm2Dcc>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0
  http://metadb.riken.jp/0000876I129129S4SvJaeSorBlackSwissMfn1tm1DccMfn1tm2DccMfn2tm1DccMfn2tm3DccTgPcp2cre2Mpin0TgPcp2cre2MpinMfn2tm3DccMfn2tm1DccMfn1tm2DccMfn1tm1Dcc
• impaired limb coordination_En1<tm2(cre)Wrst>/En1<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0001524I129129S4SvJaeSorBlackSwissEn1tm2creWrstEn1Mfn2tm1DccMfn2tm3DccMfn2tm1DccEn1En1tm2creWrstMfn2tm3Dcc
• impaired righting response_Meox2<tm1(cre)Sor>/Meox2<+>,Mfn1<tm2Dcc>/Mfn1<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0001523I129SSvEv129S4SvJaeSorBlackSwissMeox2tm1creSorMeox2Mfn1tm2DccMfn1Mfn2tm1DccMfn2tm3DccMeox2tm1creSorMfn2tm1DccMfn1tm2DccMfn2tm3DccMfn1Meox2
• abnormal axon morphology_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0
  http://metadb.riken.jp/0005404I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccTgPcp2cre2Mpin0Mfn2tm1DccTgPcp2cre2MpinMfn2tm3Dcc
• neonatal lethality, complete penetrance_Meox2<tm1(cre)Sor>/Meox2<+>,Mfn1<tm1Dcc>/Mfn1<tm2Dcc>,Mfn2<tm3Dcc>/Mfn2<+>
  http://metadb.riken.jp/0011087I129SSvEv129S4SvJaeSorBlackSwissMeox2tm1creSorMeox2Mfn1tm1DccMfn1tm2DccMfn2tm3DccMfn2Meox2Mfn2Mfn2tm3DccMeox2tm1creSorMfn1tm2DccMfn1tm1Dcc
• small cerebellum_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0
  http://metadb.riken.jp/0000852I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccTgPcp2cre2Mpin0Mfn2tm1DccTgPcp2cre2MpinMfn2tm3Dcc
• decreased body size_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0001265I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccTgWnt1cre11Rth0Mfn2tm3DccMfn2tm1DccTgWnt1cre11Rth
• impaired limb coordination_Meox2<tm1(cre)Sor>/Meox2<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0001524I129SSvEv129S4SvJaeSorBlackSwissMeox2tm1creSorMeox2Mfn2tm1DccMfn2tm3DccMfn2tm3DccMeox2Meox2tm1creSorMfn2tm1Dcc
• neonatal lethality, incomplete penetrance_Meox2<tm1(cre)Sor>/Meox2<+>,Mfn1<tm2Dcc>/Mfn1<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0011088I129SSvEv129S4SvJaeSorBlackSwissMeox2tm1creSorMeox2Mfn1tm2DccMfn1Mfn2tm1DccMfn2tm3DccMeox2tm1creSorMfn2tm1DccMfn1tm2DccMfn2tm3DccMfn1Meox2
• small cerebellum_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000852I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccTgWnt1cre11Rth0Mfn2tm3DccMfn2tm1DccTgWnt1cre11Rth
• impaired righting response_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0001523I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccTgWnt1cre11Rth0Mfn2tm3DccMfn2tm1DccTgWnt1cre11Rth
• Purkinje cell degeneration_En1<tm2(cre)Wrst>/En1<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0000876I129129S4SvJaeSorBlackSwissEn1tm2creWrstEn1Mfn2tm1DccMfn2tm3DccMfn2tm1DccEn1En1tm2creWrstMfn2tm3Dcc
• postnatal lethality, complete penetrance_Meox2<tm1(cre)Sor>/Meox2<+>,Mfn1<tm2Dcc>/Mfn1<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0011085I129SSvEv129S4SvJaeSorBlackSwissMeox2tm1creSorMeox2Mfn1tm2DccMfn1Mfn2tm1DccMfn2tm3DccMeox2tm1creSorMfn2tm1DccMfn1tm2DccMfn2tm3DccMfn1Meox2
• Purkinje cell degeneration_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0
  http://metadb.riken.jp/0000876I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccTgPcp2cre2Mpin0Mfn2tm1DccTgPcp2cre2MpinMfn2tm3Dcc
• postnatal lethality, complete penetrance_En1<tm2(cre)Wrst>/En1<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0011085I129129S4SvJaeSorBlackSwissEn1tm2creWrstEn1Mfn2tm1DccMfn2tm3DccMfn2tm1DccEn1En1tm2creWrstMfn2tm3Dcc
• increased neuron apoptosis_En1<tm2(cre)Wrst>/En1<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0003203I129129S4SvJaeSorBlackSwissEn1tm2creWrstEn1Mfn2tm1DccMfn2tm3DccMfn2tm1DccEn1En1tm2creWrstMfn2tm3Dcc
• abnormal mitochondrion morphology_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0006035I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccMfn2tm1DccMfn2tm3Dcc
• neonatal lethality, complete penetrance_Meox2<tm1(cre)Sor>/Meox2<+>,Mfn1<tm1Dcc>/Mfn1<tm2Dcc>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0011087I129SSvEv129S4SvJaeSorBlackSwissMeox2tm1creSorMeox2Mfn1tm1DccMfn1tm2DccMfn2tm1DccMfn2tm3DccMfn2tm1DccMeox2tm1creSorMfn1tm2DccMfn1tm1DccMfn2tm3DccMeox2
• postnatal lethality, complete penetrance_Meox2<tm1(cre)Sor>/Meox2<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0011085I129SSvEv129S4SvJaeSorBlackSwissMeox2tm1creSorMeox2Mfn2tm1DccMfn2tm3DccMfn2tm3DccMeox2Meox2tm1creSorMfn2tm1Dcc
• abnormal respiratory electron transport chain_Mfn1<tm1Dcc>/Mfn1<tm2Dcc>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0
  http://metadb.riken.jp/0010955I129129S4SvJaeSorBlackSwissMfn1tm1DccMfn1tm2DccMfn2tm1DccMfn2tm3DccTgPcp2cre2Mpin0TgPcp2cre2MpinMfn2tm3DccMfn2tm1DccMfn1tm2DccMfn1tm1Dcc
• abnormal mitochondrion morphology_En1<tm2(cre)Wrst>/En1<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0006035I129129S4SvJaeSorBlackSwissEn1tm2creWrstEn1Mfn2tm1DccMfn2tm3DccMfn2tm1DccEn1En1tm2creWrstMfn2tm3Dcc
• no abnormal phenotype detected_Mfn1<tm1Dcc>/Mfn1<tm2Dcc>,Mfn2<tm3Dcc>/Mfn2<+>
  http://metadb.riken.jp/0002169I129129S4SvJaeSorBlackSwissMfn1tm1DccMfn1tm2DccMfn2tm3DccMfn2Mfn2Mfn2tm3DccMfn1tm2DccMfn1tm1Dcc
• abnormal respiratory electron transport chain_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0
  http://metadb.riken.jp/0010955I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccTgPcp2cre2Mpin0Mfn2tm1DccTgPcp2cre2MpinMfn2tm3Dcc
• neonatal lethality, incomplete penetrance_Meox2<tm1(cre)Sor>/Meox2<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0011088I129SSvEv129S4SvJaeSorBlackSwissMeox2tm1creSorMeox2Mfn2tm1DccMfn2tm3DccMfn2tm3DccMeox2Meox2tm1creSorMfn2tm1Dcc
• abnormal mitochondrion morphology_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0
  http://metadb.riken.jp/0006035I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccTgPcp2cre2Mpin0Mfn2tm1DccTgPcp2cre2MpinMfn2tm3Dcc
• abnormal Purkinje cell dendrite morphology_Mfn1<tm1Dcc>/Mfn1<tm2Dcc>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0
  http://metadb.riken.jp/0008572I129129S4SvJaeSorBlackSwissMfn1tm1DccMfn1tm2DccMfn2tm1DccMfn2tm3DccTgPcp2cre2Mpin0TgPcp2cre2MpinMfn2tm3DccMfn2tm1DccMfn1tm2DccMfn1tm1Dcc
• impaired coordination_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0
  http://metadb.riken.jp/0001405I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccTgPcp2cre2Mpin0Mfn2tm1DccTgPcp2cre2MpinMfn2tm3Dcc
• no abnormal phenotype detected_Gabra6<tm2(cre)Wwis>/Gabra6<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0002169I129129S4SvJaeSorBlackSwissGabra6tm2creWwisGabra6Mfn2tm1DccMfn2tm3DccMfn2tm3DccGabra6tm2creWwisGabra6Mfn2tm1Dcc
• postnatal lethality, complete penetrance_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0011085I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccTgWnt1cre11Rth0Mfn2tm3DccMfn2tm1DccTgWnt1cre11Rth
• abnormal Purkinje cell dendrite morphology_En1<tm2(cre)Wrst>/En1<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0008572I129129S4SvJaeSorBlackSwissEn1tm2creWrstEn1Mfn2tm1DccMfn2tm3DccMfn2tm1DccEn1En1tm2creWrstMfn2tm3Dcc
• abnormal gait_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(Pcp2-cre)2Mpin/0
  http://metadb.riken.jp/0001406I129129S4SvJaeSorBlackSwissMfn2tm1DccMfn2tm3DccTgPcp2cre2Mpin0Mfn2tm1DccTgPcp2cre2MpinMfn2tm3Dcc
• small cerebellum_En1<tm2(cre)Wrst>/En1<+>,Mfn2<tm1Dcc>/Mfn2<tm3Dcc>
  http://metadb.riken.jp/0000852I129129S4SvJaeSorBlackSwissEn1tm2creWrstEn1Mfn2tm1DccMfn2tm3DccMfn2tm1DccEn1En1tm2creWrstMfn2tm3Dcc
• prenatal lethality, complete penetrance_Mfn1<tm1Dcc>/Mfn1<tm2Dcc>,Tg(EIIa-cre)C5379Lmgd/0
  http://metadb.riken.jp/0011091I129129S4SvJaeSorBlackSwissFVBNMfn1tm1DccMfn1tm2DccTgEIIacreC5379Lmgd0Mfn1tm1DccMfn1tm2DccTgEIIacreC5379Lmgd
• prenatal lethality, complete penetrance_Mfn2<tm1Dcc>/Mfn2<tm3Dcc>,Tg(EIIa-cre)C5379Lmgd/0
  http://metadb.riken.jp/0011091I129129S4SvJaeSorBlackSwissFVBNMfn2tm1DccMfn2tm3DccTgEIIacreC5379Lmgd0Mfn2tm3DccTgEIIacreC5379LmgdMfn2tm1Dcc