abnormal myelination_Tsc1<tm1Djk>/Tsc1<tm1.1Djk>,Tg(Syn1-cre)671Jxm/0

http://metadb.riken.jp/0000920I129S4SvJaeC57BL6CBATsc1tm1DjkTsc1tm11DjkTgSyn1cre671Jxm0Tsc1tm1DjkTsc1tm11DjkTgSyn1cre671Jxm

abnormal myelination_Tsc1<tm1Djk>/Tsc1<tm1.1Djk>,Tg(Syn1-cre)671Jxm/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• tuberous sclerosis 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1929183
• transgene insertion 671, Jamey Marth
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176054

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tsc1<tm1Djk>/Tsc1<tm1.1Djk>,Tg(Syn1-cre)671Jxm/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tsc1<tm1Djk>|Tsc1<tm1.1Djk>|Tg(Syn1-cre)671Jxm

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal myelination
  http://purl.obolibrary.org/obo/MP_0000920

文献

http://purl.org/net/cito/citesAsAuthority

• Lynsey. Meikle, et.al., Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 28
  http://rdf.ncbi.nlm.nih.gov/pubmed/18495876
• Lynsey. Meikle, et.al., A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 27
  http://rdf.ncbi.nlm.nih.gov/pubmed/17522300