motor neuron degeneration_Tg(SOD1*H46R*C111S)PAra/Tg(SOD1*H46R*C111S)PAra

http://metadb.riken.jp/0000938IC57BL6DBA2TgSOD1H46RC111SPAraTgSOD1H46RC111SPAraTgSOD1H46RC111SPAra

motor neuron degeneration_Tg(SOD1*H46R*C111S)PAra/Tg(SOD1*H46R*C111S)PAra

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion P, Toshiyuki Araki
  http://metadb.riken.jp/db/mgi_rdf/MGI:5699337

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(SOD1*H46R*C111S)PAra/Tg(SOD1*H46R*C111S)PAra

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(SOD1*H46R*C111S)PAra

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• motor neuron degeneration
  http://purl.obolibrary.org/obo/MP_0000938

文献

http://purl.org/net/cito/citesAsAuthority

• Seiichi. Nagano, et.al., A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice: relevance to the pathogenesis of ALS., Human molecular genetics, 2015, 24
  http://rdf.ncbi.nlm.nih.gov/pubmed/25762155