abnormal cholinergic neuron morphology_Tg(CMV-IghvaD11)DCat/0,Tg(CMV-IgkvaD11)ACat/0

http://metadb.riken.jp/0001038IC57BL6SJLTgCMVIghvaD11DCat0TgCMVIgkvaD11ACat0TgCMVIghvaD11DCatTgCMVIgkvaD11ACat

abnormal cholinergic neuron morphology_Tg(CMV-IghvaD11)DCat/0,Tg(CMV-IgkvaD11)ACat/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion A, Antonio Cattaneo
  http://metadb.riken.jp/db/mgi_rdf/MGI:3621149
• transgene insertion D, Antonio Cattaneo
  http://metadb.riken.jp/db/mgi_rdf/MGI:3721906

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(CMV-IghvaD11)DCat/0,Tg(CMV-IgkvaD11)ACat/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(CMV-IghvaD11)DCat|Tg(CMV-IgkvaD11)ACat

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal cholinergic neuron morphology
  http://purl.obolibrary.org/obo/MP_0001038

文献

http://purl.org/net/cito/citesAsAuthority

• F. Ruberti, et.al., Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/10729339
• Simona. Capsoni, et.al., Peripheral neutralization of nerve growth factor induces immunosympathectomy and central neurodegeneration in transgenic mice., Journal of Alzheimer's disease : JAD, 2010, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/20182028
• S. Capsoni, et.al., Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice., Proceedings of the National Academy of Sciences of the United States of America, 2000, 97
  http://rdf.ncbi.nlm.nih.gov/pubmed/10841577