increased metastatic potential_Pten<tm1Rdp>/Pten<tm1Rdp>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0

http://metadb.riken.jp/0001272I129C57BL6DBA2Ptentm1RdpPtentm1RdpSmad4tm1RdpSmad4tm1RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Trp53tm1BrnTgPbsncre4PrbSmad4tm1RdpPtentm1Rdp

increased metastatic potential_Pten<tm1Rdp>/Pten<tm1Rdp>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 4, Pradip Roy-Burman
  http://metadb.riken.jp/db/mgi_rdf/MGI:2388169
• SMAD family member 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:894293
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pten<tm1Rdp>/Pten<tm1Rdp>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brn>|Tg(Pbsn-cre)4Prb|Smad4<tm1Rdp>|Pten<tm1Rdp>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased metastatic potential
  http://purl.obolibrary.org/obo/MP_0001272

文献

http://purl.org/net/cito/citesAsAuthority

• Zhihu. Ding, et.al., Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases., Cell, 2012, 148
  http://rdf.ncbi.nlm.nih.gov/pubmed/22341455