Zhihu. Ding, et.al., Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases., Cell, 2012, 148

http://rdf.ncbi.nlm.nih.gov/pubmed/22341455

Zhihu. Ding, et.al., Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases., Cell, 2012, 148

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tert<tm3Rdp>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5431942

class

http://purl.org/net/cito/citesAsAuthority

• Tert<tm3Rdp>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5431942

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased prostate gland adenocarcinoma incidence_Pten<tm1Rdp>/Pten<tm1Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0009220I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Ptentm1RdpTgPbsncre4PrbTrp53tm1Brn
• increased prostate gland adenocarcinoma incidence_Pten<tm1Rdp>/Pten<tm1Rdp>,Tert<tm1Rdp>/Tert<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0009220I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTerttm1RdpTertTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Ptentm1RdpTgPbsncre4PrbTrp53tm1BrnTertTerttm1Rdp
• increased small intestinal crypt cell apoptosis_Tert<tm3Rdp>/Tert<tm3Rdp>
  http://metadb.riken.jp/0008800IC57BL6Terttm3RdpTerttm3RdpTerttm3Rdp
• decreased cell proliferation_Tert<tm3Rdp>/Tert<tm3Rdp>
  http://metadb.riken.jp/0000352IC57BL6Terttm3RdpTerttm3RdpTerttm3Rdp
• increased prostate intraepithelial neoplasia incidence_Pten<tm1Rdp>/Pten<tm1Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0009219I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Ptentm1RdpTgPbsncre4PrbTrp53tm1Brn
• premature death_Pten<tm1Rdp>/Pten<tm1Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0002083I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Ptentm1RdpTgPbsncre4PrbTrp53tm1Brn
• increased apoptosis_Tert<tm3Rdp>/Tert<tm3Rdp>
  http://metadb.riken.jp/0006042IC57BL6Terttm3RdpTerttm3RdpTerttm3Rdp
• premature death_Pten<tm1Rdp>/Pten<tm1Rdp>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0002083I129C57BL6DBA2Ptentm1RdpPtentm1RdpSmad4tm1RdpSmad4tm1RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Trp53tm1BrnTgPbsncre4PrbSmad4tm1RdpPtentm1Rdp
• increased prostate gland adenocarcinoma incidence_Pten<tm1Rdp>/Pten<tm1Rdp>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0009220I129C57BL6DBA2Ptentm1RdpPtentm1RdpSmad4tm1RdpSmad4tm1RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Trp53tm1BrnTgPbsncre4PrbSmad4tm1RdpPtentm1Rdp
• decreased testis weight_Tert<tm3Rdp>/Tert<tm3Rdp>
  http://metadb.riken.jp/0004852IC57BL6Terttm3RdpTerttm3RdpTerttm3Rdp
• premature death_Pten<tm1Rdp>/Pten<tm1Rdp>,Tert<tm3Rdp>/Tert<tm3Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0002083I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTerttm3RdpTerttm3RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Ptentm1RdpTrp53tm1BrnTgPbsncre4PrbTerttm3Rdp
• decreased body weight_Tert<tm3Rdp>/Tert<tm3Rdp>
  http://metadb.riken.jp/0001262IC57BL6Terttm3RdpTerttm3RdpTerttm3Rdp
• increased prostate intraepithelial neoplasia incidence_Pten<tm1Rdp>/Pten<tm1Rdp>,Tert<tm1Rdp>/Tert<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0009219I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTerttm1RdpTertTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Ptentm1RdpTgPbsncre4PrbTrp53tm1BrnTertTerttm1Rdp
• increased prostate gland adenocarcinoma incidence_Pten<tm1Rdp>/Pten<tm1Rdp>,Tert<tm3Rdp>/Tert<tm3Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0009220I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTerttm3RdpTerttm3RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Ptentm1RdpTrp53tm1BrnTgPbsncre4PrbTerttm3Rdp
• increased metastatic potential_Pten<tm1Rdp>/Pten<tm1Rdp>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0001272I129C57BL6DBA2Ptentm1RdpPtentm1RdpSmad4tm1RdpSmad4tm1RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Trp53tm1BrnTgPbsncre4PrbSmad4tm1RdpPtentm1Rdp
• abnormal chromosome morphology_Pten<tm1Rdp>/Pten<tm1Rdp>,Tert<tm3Rdp>/Tert<tm3Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0003702I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTerttm3RdpTerttm3RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Ptentm1RdpTrp53tm1BrnTgPbsncre4PrbTerttm3Rdp
• premature death_Pten<tm1Rdp>/Pten<tm1Rdp>,Tert<tm1Rdp>/Tert<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0002083I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTerttm1RdpTertTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Ptentm1RdpTgPbsncre4PrbTrp53tm1BrnTertTerttm1Rdp
• testicular atrophy_Tert<tm3Rdp>/Tert<tm3Rdp>
  http://metadb.riken.jp/0003205IC57BL6Terttm3RdpTerttm3RdpTerttm3Rdp
• abnormal telomere length_Pten<tm1Rdp>/Pten<tm1Rdp>,Tert<tm1Rdp>/Tert<tm1Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0003155I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTerttm1RdpTerttm1RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Trp53tm1BrnTgPbsncre4PrbPtentm1RdpTerttm1Rdp
• increased metastatic potential_Pten<tm1Rdp>/Pten<tm1Rdp>,Tert<tm3Rdp>/Tert<tm3Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0001272I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTerttm3RdpTerttm3RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Ptentm1RdpTrp53tm1BrnTgPbsncre4PrbTerttm3Rdp
• increased prostate intraepithelial neoplasia incidence_Pten<tm1Rdp>/Pten<tm1Rdp>,Tert<tm1Rdp>/Tert<tm1Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0009219I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTerttm1RdpTerttm1RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Trp53tm1BrnTgPbsncre4PrbPtentm1RdpTerttm1Rdp
• abnormal telomere length_Pten<tm1Rdp>/Pten<tm1Rdp>,Tert<tm3Rdp>/Tert<tm3Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0003155I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTerttm3RdpTerttm3RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Ptentm1RdpTrp53tm1BrnTgPbsncre4PrbTerttm3Rdp
• increased prostate intraepithelial neoplasia incidence_Pten<tm1Rdp>/Pten<tm1Rdp>,Tert<tm3Rdp>/Tert<tm3Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0009219I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTerttm3RdpTerttm3RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Ptentm1RdpTrp53tm1BrnTgPbsncre4PrbTerttm3Rdp
• decreased tumor growth/size_Pten<tm1Rdp>/Pten<tm1Rdp>,Tert<tm1Rdp>/Tert<tm1Rdp>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pbsn-cre)4Prb/0
  http://metadb.riken.jp/0003447I129P2OlaHsd129S6SvEvTacC57BL6DBA2Ptentm1RdpPtentm1RdpTerttm1RdpTerttm1RdpTrp53tm1BrnTrp53tm1BrnTgPbsncre4Prb0Trp53tm1BrnTgPbsncre4PrbPtentm1RdpTerttm1Rdp