increased metastatic potential_Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-EGFR*T790M*L858R)19Kkw/0

http://metadb.riken.jp/0001272I129C57BL6FVBNTgScgb1a1rtTA1Jaw0TgtetOEGFRT790ML858R19Kkw0TgtetOEGFRT790ML858R19KkwTgScgb1a1rtTA1Jaw

increased metastatic potential_Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-EGFR*T790M*L858R)19Kkw/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Jeffrey A Whitsett
  http://metadb.riken.jp/db/mgi_rdf/MGI:2652186
• transgene insertion 19, Kwok-Kin Wong
  http://metadb.riken.jp/db/mgi_rdf/MGI:5781127

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-EGFR*T790M*L858R)19Kkw/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(tetO-EGFR*T790M*L858R)19Kkw|Tg(Scgb1a1-rtTA)1Jaw

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased metastatic potential
  http://purl.obolibrary.org/obo/MP_0001272

文献

http://purl.org/net/cito/citesAsAuthority

• Danan. Li, et.al., Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy., Cancer cell, 2007, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/17613438