Danan. Li, et.al., Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy., Cancer cell, 2007, 12

http://rdf.ncbi.nlm.nih.gov/pubmed/17613438

Danan. Li, et.al., Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy., Cancer cell, 2007, 12

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-EGFR*T790M*L858R)19Kkw
  http://metadb.riken.jp/db/mgi_rdf/MGI:5781130

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased lung tumor incidence_Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-EGFR*T790M*L858R)19Kkw/0
  http://metadb.riken.jp/0008014I129C57BL6FVBNTgScgb1a1rtTA1Jaw0TgtetOEGFRT790ML858R19Kkw0TgtetOEGFRT790ML858R19KkwTgScgb1a1rtTA1Jaw
• increased lung carcinoma incidence_Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-EGFR*T790M*L858R)19Kkw/0
  http://metadb.riken.jp/0008714I129C57BL6FVBNTgScgb1a1rtTA1Jaw0TgtetOEGFRT790ML858R19Kkw0TgtetOEGFRT790ML858R19KkwTgScgb1a1rtTA1Jaw
• interstitial pneumonia_Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-EGFR*T790M*L858R)19Kkw/0
  http://metadb.riken.jp/0001862I129C57BL6FVBNTgScgb1a1rtTA1Jaw0TgtetOEGFRT790ML858R19Kkw0TgtetOEGFRT790ML858R19KkwTgScgb1a1rtTA1Jaw
• increased metastatic potential_Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-EGFR*T790M*L858R)19Kkw/0
  http://metadb.riken.jp/0001272I129C57BL6FVBNTgScgb1a1rtTA1Jaw0TgtetOEGFRT790ML858R19Kkw0TgtetOEGFRT790ML858R19KkwTgScgb1a1rtTA1Jaw
• increased lung adenocarcinoma incidence_Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-EGFR*T790M*L858R)19Kkw/0
  http://metadb.riken.jp/0002027I129C57BL6FVBNTgScgb1a1rtTA1Jaw0TgtetOEGFRT790ML858R19Kkw0TgtetOEGFRT790ML858R19KkwTgScgb1a1rtTA1Jaw

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-EGFR*T790M*L858R)19Kkw
  http://metadb.riken.jp/db/mgi_rdf/MGI:5781130