increased metastatic potential_Braf<tm1Mmcm>/Braf<+>,Pten<tm1Rdp>/Pten<tm1Rdp>,Tg(Tyr-cre/ERT2)13Bos/0

http://metadb.riken.jp/0001272I129P2OlaHsd129S6SvEvTacC57BL6FVBNBraftm1MmcmBrafPtentm1RdpPtentm1RdpTgTyrcreERT213Bos0Ptentm1RdpBraftm1MmcmBrafTgTyrcreERT213Bos

increased metastatic potential_Braf<tm1Mmcm>/Braf<+>,Pten<tm1Rdp>/Pten<tm1Rdp>,Tg(Tyr-cre/ERT2)13Bos/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• Braf transforming gene
  http://metadb.riken.jp/db/mgi_rdf/MGI:88190
• transgene insertion 13, Marcus Bosenberg
  http://metadb.riken.jp/db/mgi_rdf/MGI:3641202

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Braf<tm1Mmcm>/Braf<+>,Pten<tm1Rdp>/Pten<tm1Rdp>,Tg(Tyr-cre/ERT2)13Bos/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pten<tm1Rdp>|Braf<tm1Mmcm>|Braf<+>|Tg(Tyr-cre/ERT2)13Bos

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased metastatic potential
  http://purl.obolibrary.org/obo/MP_0001272

文献

http://purl.org/net/cito/citesAsAuthority

• David. Dankort, et.al., Braf(V600E) cooperates with Pten loss to induce metastatic melanoma., Nature genetics, 2009, 41
  http://rdf.ncbi.nlm.nih.gov/pubmed/19282848