David. Dankort, et.al., Braf(V600E) cooperates with Pten loss to induce metastatic melanoma., Nature genetics, 2009, 41

http://rdf.ncbi.nlm.nih.gov/pubmed/19282848

David. Dankort, et.al., Braf(V600E) cooperates with Pten loss to induce metastatic melanoma., Nature genetics, 2009, 41

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• skin lesions_Braf<tm1Mmcm>/Braf<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0001212I129P2OlaHsdFVBBraftm1MmcmBrafTgTyrcreERT213Bos0Braftm1MmcmBrafTgTyrcreERT213Bos
• increased cutaneous melanoma incidence_Braf<tm1Mmcm>/Braf<+>,Pten<tm2.1Ppp>/Pten<tm2.1Ppp>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010322I129P2OlaHsd129S1SvFVBBraftm1MmcmBrafPtentm21PppPtentm21PppTgTyrcreERT213Bos0BrafTgTyrcreERT213BosBraftm1MmcmPtentm21Ppp
• abnormal melanocyte morphology_Braf<tm1Mmcm>/Braf<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0002877I129P2OlaHsdFVBBraftm1MmcmBrafTgTyrcreERT213Bos0Braftm1MmcmBrafTgTyrcreERT213Bos
• increased metastatic potential_Braf<tm1Mmcm>/Braf<+>,Pten<tm1Rdp>/Pten<tm1Rdp>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0001272I129P2OlaHsd129S6SvEvTacC57BL6FVBNBraftm1MmcmBrafPtentm1RdpPtentm1RdpTgTyrcreERT213Bos0Ptentm1RdpBraftm1MmcmBrafTgTyrcreERT213Bos
• increased cutaneous melanoma incidence_Braf<tm1Mmcm>/Braf<+>,Pten<tm2.1Ppp>/Pten<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010322I129P2OlaHsd129S1SvFVBBraftm1MmcmBrafPtentm21PppPtenTgTyrcreERT213Bos0Ptentm21PppBraftm1MmcmBrafPtenTgTyrcreERT213Bos
• abnormal melanocyte morphology_Braf<tm1Mmcm>/Braf<tm1Mmcm>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0002877I129P2OlaHsdFVBBraftm1MmcmBraftm1MmcmTgTyrcreERT213Bos0TgTyrcreERT213BosBraftm1Mmcm
• abnormal melanocyte morphology_Braf<tm1Mmcm>/Braf<+>,Pten<tm2.1Ppp>/Pten<+>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0002877I129P2OlaHsd129S1SvFVBBraftm1MmcmBrafPtentm21PppPtenTgTyrcreERT213Bos0Ptentm21PppBraftm1MmcmBrafPtenTgTyrcreERT213Bos
• increased cutaneous melanoma incidence_Braf<tm1Mmcm>/Braf<+>,Pten<tm1Rdp>/Pten<tm1Rdp>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0010322I129P2OlaHsd129S6SvEvTacC57BL6FVBNBraftm1MmcmBrafPtentm1RdpPtentm1RdpTgTyrcreERT213Bos0Ptentm1RdpBraftm1MmcmBrafTgTyrcreERT213Bos
• increased metastatic potential_Braf<tm1Mmcm>/Braf<+>,Pten<tm2.1Ppp>/Pten<tm2.1Ppp>,Tg(Tyr-cre/ERT2)13Bos/0
  http://metadb.riken.jp/0001272I129P2OlaHsd129S1SvFVBBraftm1MmcmBrafPtentm21PppPtentm21PppTgTyrcreERT213Bos0BrafTgTyrcreERT213BosBraftm1MmcmPtentm21Ppp