increased metastatic potential_Brca1<tm2Cxd>/Brca1<tm2Cxd>,Pkm<tm1.1Mgvh>/Pkm<tm1.1Mgvh>,Tg(MMTV-cre)4Mam/0,Trp53<tm1Brd>/Trp53<+>

http://metadb.riken.jp/0001272I129S4SvJaeSor129S6SvEvTac129S7SvEvBrdFVBNBrca1tm2CxdBrca1tm2CxdPkmtm11MgvhPkmtm11MgvhTgMMTVcre4Mam0Trp53tm1BrdTrp53Trp53tm1BrdBrca1tm2CxdPkmtm11MgvhTrp53TgMMTVcre4Mam

increased metastatic potential_Brca1<tm2Cxd>/Brca1<tm2Cxd>,Pkm<tm1.1Mgvh>/Pkm<tm1.1Mgvh>,Tg(MMTV-cre)4Mam/0,Trp53<tm1Brd>/Trp53<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• pyruvate kinase, muscle
  http://metadb.riken.jp/db/mgi_rdf/MGI:97591
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 4, Lothar Hennighausen
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176163
• breast cancer 1, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:104537

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca1<tm2Cxd>/Brca1<tm2Cxd>,Pkm<tm1.1Mgvh>/Pkm<tm1.1Mgvh>,Tg(MMTV-cre)4Mam/0,Trp53<tm1Brd>/Trp53<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brd>|Brca1<tm2Cxd>|Pkm<tm1.1Mgvh>|Trp53<+>|Tg(MMTV-cre)4Mam

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased metastatic potential
  http://purl.obolibrary.org/obo/MP_0001272

文献

http://purl.org/net/cito/citesAsAuthority

• William J. Israelsen, et.al., PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells., Cell, 2013, 155
  http://rdf.ncbi.nlm.nih.gov/pubmed/24120138