William J. Israelsen, et.al., PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells., Cell, 2013, 155

http://rdf.ncbi.nlm.nih.gov/pubmed/24120138

William J. Israelsen, et.al., PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells., Cell, 2013, 155

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Pkm<tm1.1Mgvh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5547750

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• no abnormal phenotype detected_Pkm<tm1.1Mgvh>/Pkm<tm1.1Mgvh>
  http://metadb.riken.jp/0002169I129S4SvJaeSor129S6SvEvTacPkmtm11MgvhPkmtm11MgvhPkmtm11Mgvh
• increased liver tumor incidence_Brca1<tm2Cxd>/Brca1<tm2Cxd>,Pkm<tm1.1Mgvh>/Pkm<tm1.1Mgvh>,Tg(MMTV-cre)4Mam/0,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0008019I129S4SvJaeSor129S6SvEvTac129S7SvEvBrdFVBNBrca1tm2CxdBrca1tm2CxdPkmtm11MgvhPkmtm11MgvhTgMMTVcre4Mam0Trp53tm1BrdTrp53Trp53tm1BrdBrca1tm2CxdPkmtm11MgvhTrp53TgMMTVcre4Mam
• increased metastatic potential_Brca1<tm2Cxd>/Brca1<tm2Cxd>,Pkm<tm1.1Mgvh>/Pkm<tm1.1Mgvh>,Tg(MMTV-cre)4Mam/0,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0001272I129S4SvJaeSor129S6SvEvTac129S7SvEvBrdFVBNBrca1tm2CxdBrca1tm2CxdPkmtm11MgvhPkmtm11MgvhTgMMTVcre4Mam0Trp53tm1BrdTrp53Trp53tm1BrdBrca1tm2CxdPkmtm11MgvhTrp53TgMMTVcre4Mam
• increased mammary gland tumor incidence_Brca1<tm2Cxd>/Brca1<tm2Cxd>,Pkm<tm1.1Mgvh>/Pkm<tm1.1Mgvh>,Tg(MMTV-cre)4Mam/0,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0010299I129S4SvJaeSor129S6SvEvTac129S7SvEvBrdFVBNBrca1tm2CxdBrca1tm2CxdPkmtm11MgvhPkmtm11MgvhTgMMTVcre4Mam0Trp53tm1BrdTrp53Trp53tm1BrdBrca1tm2CxdPkmtm11MgvhTrp53TgMMTVcre4Mam
• premature death_Brca1<tm2Cxd>/Brca1<tm2Cxd>,Pkm<tm1.1Mgvh>/Pkm<tm1.1Mgvh>,Tg(MMTV-cre)4Mam/0,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0002083I129S4SvJaeSor129S6SvEvTac129S7SvEvBrdFVBNBrca1tm2CxdBrca1tm2CxdPkmtm11MgvhPkmtm11MgvhTgMMTVcre4Mam0Trp53tm1BrdTrp53Trp53tm1BrdBrca1tm2CxdPkmtm11MgvhTrp53TgMMTVcre4Mam

class

http://purl.org/net/cito/citesAsAuthority

• Pkm<tm1.1Mgvh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5547750