impaired coordination_Mapt<tm1(Setdb1)Akba>/Mapt<+>,Mecp2<tm1Jae>/Y,Tg(Nes-cre)1Atp/0

http://metadb.riken.jp/0001405I129S4SvJae129S7SvEvBrdC57BL6FVBNMapttm1Setdb1AkbaMaptMecp2tm1JaeYTgNescre1Atp0MaptTgNescre1AtpMapttm1Setdb1AkbaMecp2tm1Jae

impaired coordination_Mapt<tm1(Setdb1)Akba>/Mapt<+>,Mecp2<tm1Jae>/Y,Tg(Nes-cre)1Atp/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Andreas Trumpp
  http://metadb.riken.jp/db/mgi_rdf/MGI:3687337
• microtubule-associated protein tau
  http://metadb.riken.jp/db/mgi_rdf/MGI:97180
• methyl CpG binding protein 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:99918

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mapt<tm1(Setdb1)Akba>/Mapt<+>,Mecp2<tm1Jae>/Y,Tg(Nes-cre)1Atp/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mapt<+>|Tg(Nes-cre)1Atp|Mapt<tm1(Setdb1)Akba>|Mecp2<tm1Jae>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• impaired coordination
  http://purl.obolibrary.org/obo/MP_0001405

文献

http://purl.org/net/cito/citesAsAuthority

• Yan. Jiang, et.al., Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice., Neuropharmacology, 2011, 60
  http://rdf.ncbi.nlm.nih.gov/pubmed/20869373