hyperglycemia_Irs2<tm1Mfw>/Irs2<tm1Mfw>

http://metadb.riken.jp/0001559I129S1Sv129X1SvJC57BL6JIrs2tm1MfwIrs2tm1MfwIrs2tm1Mfw

hyperglycemia_Irs2<tm1Mfw>/Irs2<tm1Mfw>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• insulin receptor substrate 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:109334

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Irs2<tm1Mfw>/Irs2<tm1Mfw>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Irs2<tm1Mfw>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• hyperglycemia
  http://purl.obolibrary.org/obo/MP_0001559

文献

http://purl.org/net/cito/citesAsAuthority

• Tohru. Uchida, et.al., Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice., Nature medicine, 2005, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/15685168
• Katsuya. Tanabe, et.al., Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance., PLoS biology, 2008, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/18288891
• Anita M. Hennige, et.al., Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes., The Journal of clinical investigation, 2003, 112
  http://rdf.ncbi.nlm.nih.gov/pubmed/14617753
• D J. Withers, et.al., Disruption of IRS-2 causes type 2 diabetes in mice., Nature, 1998, 391
  http://rdf.ncbi.nlm.nih.gov/pubmed/9495343