Katsuya. Tanabe, et.al., Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance., PLoS biology, 2008, 6

http://rdf.ncbi.nlm.nih.gov/pubmed/18288891

Katsuya. Tanabe, et.al., Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance., PLoS biology, 2008, 6

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gsk3b<tm2Jrw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3794785

class

http://purl.org/net/cito/citesAsAuthority

• Gsk3b<tm2Jrw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3794785

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• insulin resistance_Gsk3b<tm1Jrw>/Gsk3b<+>,Irs2<tm1Mfw>/Irs2<tm1Mfw>
  http://metadb.riken.jp/0005331I129S1Sv129X1SvJC57BL6JGsk3btm1JrwGsk3bIrs2tm1MfwIrs2tm1MfwGsk3btm1JrwGsk3bIrs2tm1Mfw
• increased circulating insulin level_Insr<tm1Dac>/Insr<+>
  http://metadb.riken.jp/0002079I129C57BL6JInsrtm1DacInsrInsrInsrtm1Dac
• abnormal glucose homeostasis_Gsk3b<tm1Jrw>/Gsk3b<+>
  http://metadb.riken.jp/0002078I129C57BL6JGsk3btm1JrwGsk3bGsk3bGsk3btm1Jrw
• abnormal circulating glucose level_Gsk3b<tm1Jrw>/Gsk3b<+>,Insr<tm1Dac>/Insr<+>
  http://metadb.riken.jp/0000188I129C57BL6JGsk3btm1JrwGsk3bInsrtm1DacInsrGsk3btm1JrwInsrtm1DacInsrGsk3b
• decreased circulating insulin level_Gsk3b<tm1Jrw>/Gsk3b<+>
  http://metadb.riken.jp/0002727I129C57BL6JGsk3btm1JrwGsk3bGsk3bGsk3btm1Jrw
• insulin resistance_Gsk3b<tm1Jrw>/Gsk3b<+>,Insr<tm1Dac>/Insr<+>
  http://metadb.riken.jp/0005331I129C57BL6JGsk3btm1JrwGsk3bInsrtm1DacInsrGsk3btm1JrwInsrtm1DacInsrGsk3b
• abnormal circulating glucose level_Gsk3b<tm1Jrw>/Gsk3b<+>,Irs2<tm1Mfw>/Irs2<tm1Mfw>
  http://metadb.riken.jp/0000188I129S1Sv129X1SvJC57BL6JGsk3btm1JrwGsk3bIrs2tm1MfwIrs2tm1MfwGsk3btm1JrwGsk3bIrs2tm1Mfw
• improved glucose tolerance_Gsk3b<tm1Jrw>/Gsk3b<+>,Insr<tm1Dac>/Insr<+>
  http://metadb.riken.jp/0005292I129C57BL6JGsk3btm1JrwGsk3bInsrtm1DacInsrGsk3btm1JrwInsrtm1DacInsrGsk3b
• abnormal circulating glucose level_Gsk3b<tm2Jrw>/Gsk3b<tm2Jrw>,Irs2<tm1Mfw>/Irs2<tm1Mfw>,Tg(Ins2-cre)23Herr/?
  http://metadb.riken.jp/0000188I129S1Sv129X1SvJC57BL6JCBAJGsk3btm2JrwGsk3btm2JrwIrs2tm1MfwIrs2tm1MfwTgIns2cre23HerrTgIns2cre23HerrGsk3btm2JrwIrs2tm1Mfw
• hyperglycemia_Irs2<tm1Mfw>/Irs2<tm1Mfw>
  http://metadb.riken.jp/0001559I129S1Sv129X1SvJC57BL6JIrs2tm1MfwIrs2tm1MfwIrs2tm1Mfw
• decreased pancreatic beta cell mass_Gsk3b<tm1Jrw>/Gsk3b<+>,Insr<tm1Dac>/Insr<+>
  http://metadb.riken.jp/0009114I129C57BL6JGsk3btm1JrwGsk3bInsrtm1DacInsrGsk3btm1JrwInsrtm1DacInsrGsk3b
• increased circulating insulin level_Irs2<tm1Mfw>/Irs2<tm1Mfw>
  http://metadb.riken.jp/0002079I129S1Sv129X1SvJC57BL6JIrs2tm1MfwIrs2tm1MfwIrs2tm1Mfw
• abnormal pancreatic beta cell morphology_Gsk3b<tm1Jrw>/Gsk3b<+>,Irs2<tm1Mfw>/Irs2<tm1Mfw>
  http://metadb.riken.jp/0005217I129S1Sv129X1SvJC57BL6JGsk3btm1JrwGsk3bIrs2tm1MfwIrs2tm1MfwGsk3btm1JrwGsk3bIrs2tm1Mfw
• increased circulating glucose level_Gsk3b<tm1Jrw>/Gsk3b<+>,Irs2<tm1Mfw>/Irs2<tm1Mfw>
  http://metadb.riken.jp/0005559I129S1Sv129X1SvJC57BL6JGsk3btm1JrwGsk3bIrs2tm1MfwIrs2tm1MfwGsk3btm1JrwGsk3bIrs2tm1Mfw
• increased circulating insulin level_Gsk3b<tm1Jrw>/Gsk3b<+>,Irs2<tm1Mfw>/Irs2<tm1Mfw>
  http://metadb.riken.jp/0002079I129S1Sv129X1SvJC57BL6JGsk3btm1JrwGsk3bIrs2tm1MfwIrs2tm1MfwGsk3btm1JrwGsk3bIrs2tm1Mfw
• increased circulating insulin level_Gsk3b<tm2Jrw>/Gsk3b<tm2Jrw>,Irs2<tm1Mfw>/Irs2<tm1Mfw>,Tg(Ins2-cre)23Herr/?
  http://metadb.riken.jp/0002079I129S1Sv129X1SvJC57BL6JCBAJGsk3btm2JrwGsk3btm2JrwIrs2tm1MfwIrs2tm1MfwTgIns2cre23HerrTgIns2cre23HerrGsk3btm2JrwIrs2tm1Mfw
• insulin resistance_Irs2<tm1Mfw>/Irs2<tm1Mfw>
  http://metadb.riken.jp/0005331I129S1Sv129X1SvJC57BL6JIrs2tm1MfwIrs2tm1MfwIrs2tm1Mfw
• decreased circulating glucose level_Gsk3b<tm1Jrw>/Gsk3b<+>
  http://metadb.riken.jp/0005560I129C57BL6JGsk3btm1JrwGsk3bGsk3bGsk3btm1Jrw
• decreased pancreatic beta cell mass_Irs2<tm1Mfw>/Irs2<tm1Mfw>
  http://metadb.riken.jp/0009114I129S1Sv129X1SvJC57BL6JIrs2tm1MfwIrs2tm1MfwIrs2tm1Mfw
• insulin resistance_Insr<tm1Dac>/Insr<+>
  http://metadb.riken.jp/0005331I129C57BL6JInsrtm1DacInsrInsrInsrtm1Dac
• abnormal circulating insulin level_Gsk3b<tm1Jrw>/Gsk3b<+>,Insr<tm1Dac>/Insr<+>
  http://metadb.riken.jp/0001560I129C57BL6JGsk3btm1JrwGsk3bInsrtm1DacInsrGsk3btm1JrwInsrtm1DacInsrGsk3b
• weight loss_Irs2<tm1Mfw>/Irs2<tm1Mfw>
  http://metadb.riken.jp/0001263I129S1Sv129X1SvJC57BL6JIrs2tm1MfwIrs2tm1MfwIrs2tm1Mfw
• increased pancreatic beta cell mass_Insr<tm1Dac>/Insr<+>
  http://metadb.riken.jp/0009113I129C57BL6JInsrtm1DacInsrInsrInsrtm1Dac