hepatic necrosis_Mapk3<tm1Gpg>/Mapk3<tm1Gpg>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0

http://metadb.riken.jp/0001654I129SvC3HC57BL6FVBNMapk3tm1GpgMapk3tm1GpgTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk3tm1Gpg

hepatic necrosis_Mapk3<tm1Gpg>/Mapk3<tm1Gpg>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• mitogen-activated protein kinase 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:1346859
• transgene insertion 12, Richard A Flavell
  http://metadb.riken.jp/db/mgi_rdf/MGI:2136409
• transgene insertion 1, Jeffrey Robbins
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822047

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mapk3<tm1Gpg>/Mapk3<tm1Gpg>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(CAG-cat,-Ptpn11*Q97R)1Rbns|Tg(Tek-cre)12Flv|Mapk3<tm1Gpg>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * C3H * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• hepatic necrosis
  http://purl.obolibrary.org/obo/MP_0001654

文献

http://purl.org/net/cito/citesAsAuthority

• Maike. Krenz, et.al., Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome., Proceedings of the National Academy of Sciences of the United States of America, 2008, 105
  http://rdf.ncbi.nlm.nih.gov/pubmed/19017799