Maike. Krenz, et.al., Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome., Proceedings of the National Academy of Sciences of the United States of America, 2008, 105

http://rdf.ncbi.nlm.nih.gov/pubmed/19017799

Maike. Krenz, et.al., Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome., Proceedings of the National Academy of Sciences of the United States of America, 2008, 105

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(CAG-cat,-Ptpn11*Q97R)1Rbns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822129
• Tg(CAG-cat,-Map2k1*)1Rbns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822131
• Tg(CAG-cat,-Ptpn11)1Rbns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822130

class

http://purl.org/net/cito/citesAsAuthority

• Tg(CAG-cat,-Ptpn11*Q97R)1Rbns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822129
• Tg(CAG-cat,-Map2k1*)1Rbns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822131
• Tg(CAG-cat,-Ptpn11)1Rbns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822130

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• prenatal lethality, complete penetrance_Tg(CAG-cat,-Map2k1*)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0011091IC3HC57BL6FVBNTgCAGcatMap2k11Rbns0TgTekcre12Flv0TgTekcre12FlvTgCAGcatMap2k11Rbns
• nuchal edema_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0012269IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• hepatic necrosis_Mapk1<tm1Melo>/Mapk1<+>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0001654I129S2SvPasC3HC57BL6FVBNMapk1tm1MeloMapk1TgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk1tm1MeloMapk1
• ventricular septal defect_Mapk1<tm1Melo>/Mapk1<+>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0010402I129S2SvPasC3HC57BL6FVBNMapk1tm1MeloMapk1TgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk1tm1MeloMapk1
• embryonic lethality during organogenesis, incomplete penetrance_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0011108IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• abnormal atrioventricular cushion morphology_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0000297IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• decreased embryo size_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0001698IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• edema_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0001785IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• abnormal cardiovascular system physiology_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0001544IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• hepatic necrosis_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0001654IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• lethality throughout fetal growth and development, complete penetrance_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0011099IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• increased atrioventricular cushion size_Mapk1<tm1Melo>/Mapk1<+>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0003808I129S2SvPasC3HC57BL6FVBNMapk1tm1MeloMapk1TgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk1tm1MeloMapk1
• ventricular septal defect_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0010402IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• small liver_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0000601IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• abnormal cardiovascular system physiology_Mapk1<tm1Melo>/Mapk1<+>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0001544I129S2SvPasC3HC57BL6FVBNMapk1tm1MeloMapk1TgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk1tm1MeloMapk1
• double outlet right ventricle_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0000284IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• ventricular cardiomyopathy_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0002952IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• embryonic lethality during organogenesis, complete penetrance_Mapk3<tm1Gpg>/Mapk3<+>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0011098I129SvC3HC57BL6FVBNMapk3tm1GpgMapk3TgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0Mapk3tm1GpgTgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk3
• nuchal edema_Mapk3<tm1Gpg>/Mapk3<+>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0012269I129SvC3HC57BL6FVBNMapk3tm1GpgMapk3TgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0Mapk3tm1GpgTgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk3
• nuchal edema_Mapk1<tm1Melo>/Mapk1<+>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0012269I129S2SvPasC3HC57BL6FVBNMapk1tm1MeloMapk1TgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk1tm1MeloMapk1
• increased atrioventricular cushion size_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0003808IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• hepatic necrosis_Mapk3<tm1Gpg>/Mapk3<+>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0001654I129SvC3HC57BL6FVBNMapk3tm1GpgMapk3TgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0Mapk3tm1GpgTgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk3
• conotruncal ridge hyperplasia_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0010588IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• embryonic lethality during organogenesis, complete penetrance_Mapk3<tm1Gpg>/Mapk3<tm1Gpg>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0011098I129SvC3HC57BL6FVBNMapk3tm1GpgMapk3tm1GpgTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk3tm1Gpg
• embryonic lethality during organogenesis, complete penetrance_Mapk1<tm1Melo>/Mapk1<+>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0011098I129S2SvPasC3HC57BL6FVBNMapk1tm1MeloMapk1TgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk1tm1MeloMapk1
• double outlet right ventricle_Mapk1<tm1Melo>/Mapk1<+>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0000284I129S2SvPasC3HC57BL6FVBNMapk1tm1MeloMapk1TgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk1tm1MeloMapk1
• increased atrioventricular cushion size_Tg(CAG-cat,-Map2k1*)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0003808IC3HC57BL6FVBNTgCAGcatMap2k11Rbns0TgTekcre12Flv0TgTekcre12FlvTgCAGcatMap2k11Rbns
• increased atrioventricular cushion size_Mapk3<tm1Gpg>/Mapk3<+>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0003808I129SvC3HC57BL6FVBNMapk3tm1GpgMapk3TgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0Mapk3tm1GpgTgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk3
• hemorrhage_Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0001914IC3HC57BL6FVBNTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12Flv
• nuchal edema_Mapk3<tm1Gpg>/Mapk3<tm1Gpg>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0012269I129SvC3HC57BL6FVBNMapk3tm1GpgMapk3tm1GpgTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk3tm1Gpg
• hepatic necrosis_Mapk3<tm1Gpg>/Mapk3<tm1Gpg>,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0001654I129SvC3HC57BL6FVBNMapk3tm1GpgMapk3tm1GpgTgCAGcatPtpn11Q97R1Rbns0TgTekcre12Flv0TgCAGcatPtpn11Q97R1RbnsTgTekcre12FlvMapk3tm1Gpg