increased mammary adenocarcinoma incidence_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(MMTV-cre)7Mul/0

http://metadb.riken.jp/0001883I129P2OlaHsd129S6SvEvTacFVBNSmad4tm21CxdSmad4tm21CxdTrp53tm1BrnTrp53tm1BrnTgMMTVcre7Mul0TgMMTVcre7MulTrp53tm1BrnSmad4tm21Cxd

increased mammary adenocarcinoma incidence_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(MMTV-cre)7Mul/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 7, William J Muller
  http://metadb.riken.jp/db/mgi_rdf/MGI:3589277
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• SMAD family member 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:894293

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(MMTV-cre)7Mul/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(MMTV-cre)7Mul|Trp53<tm1Brn>|Smad4<tm2.1Cxd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased mammary adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0001883

文献

http://purl.org/net/cito/citesAsAuthority

• Jun Won. Park, et.al., Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis., Molecular cancer research : MCR, 2014, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/24784840