increased mammary adenocarcinoma incidence_Pten<tm2Mak>/Pten<tm2Mak>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Wap-cre)11738Mam/0

http://metadb.riken.jp/0001883I129P2OlaHsdC57BL6FVBNSJLPtentm2MakPtentm2MakTrp53tm1BrnTrp53tm1BrnTgWapcre11738Mam0TgWapcre11738MamTrp53tm1BrnPtentm2Mak

increased mammary adenocarcinoma incidence_Pten<tm2Mak>/Pten<tm2Mak>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Wap-cre)11738Mam/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 11738, Lothar Hennighausen
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176164

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pten<tm2Mak>/Pten<tm2Mak>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Wap-cre)11738Mam/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Wap-cre)11738Mam|Trp53<tm1Brn>|Pten<tm2Mak>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased mammary adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0001883

文献

http://purl.org/net/cito/citesAsAuthority

• Jeff C. Liu, et.al., Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K., EMBO molecular medicine, 2014, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/25330770