reduced NMDA-mediated synaptic currents_Vps35<Gt(RRK261)Byg>/Vps35<+>,Tg(APPSWE)2576Kha/0

http://metadb.riken.jp/0001902I129P2OlaHsdC57BL6SJLVps35GtRRK261BygVps35TgAPPSWE2576Kha0Vps35GtRRK261BygVps35TgAPPSWE2576Kha

reduced NMDA-mediated synaptic currents_Vps35<Gt(RRK261)Byg>/Vps35<+>,Tg(APPSWE)2576Kha/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• VPS35 retromer complex component
  http://metadb.riken.jp/db/mgi_rdf/MGI:1890467
• transgene insertion 2576, Karen Hsiao Ashe
  http://metadb.riken.jp/db/mgi_rdf/MGI:2385632

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Vps35<Gt(RRK261)Byg>/Vps35<+>,Tg(APPSWE)2576Kha/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Vps35<Gt(RRK261)Byg>|Vps35<+>|Tg(APPSWE)2576Kha

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• reduced NMDA-mediated synaptic currents
  http://purl.obolibrary.org/obo/MP_0001902

文献

http://purl.org/net/cito/citesAsAuthority

• Lei. Wen, et.al., VPS35 haploinsufficiency increases Alzheimer's disease neuropathology., The Journal of cell biology, 2011, 195
  http://rdf.ncbi.nlm.nih.gov/pubmed/22105352