Lei. Wen, et.al., VPS35 haploinsufficiency increases Alzheimer's disease neuropathology., The Journal of cell biology, 2011, 195

http://rdf.ncbi.nlm.nih.gov/pubmed/22105352

Lei. Wen, et.al., VPS35 haploinsufficiency increases Alzheimer's disease neuropathology., The Journal of cell biology, 2011, 195

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal miniature excitatory postsynaptic currents_Vps35<Gt(RRK261)Byg>/Vps35<+>,Tg(APPSWE)2576Kha/0
  http://metadb.riken.jp/0004753I129P2OlaHsdC57BL6SJLVps35GtRRK261BygVps35TgAPPSWE2576Kha0Vps35GtRRK261BygVps35TgAPPSWE2576Kha
• amyloid beta deposits_Vps35<Gt(RRK261)Byg>/Vps35<+>,Tg(APPSWE)2576Kha/0
  http://metadb.riken.jp/0003329I129P2OlaHsdC57BL6SJLVps35GtRRK261BygVps35TgAPPSWE2576Kha0Vps35GtRRK261BygVps35TgAPPSWE2576Kha
• reduced AMPA-mediated synaptic currents_Vps35<Gt(RRK261)Byg>/Vps35<+>,Tg(APPSWE)2576Kha/0
  http://metadb.riken.jp/0011003I129P2OlaHsdC57BL6SJLVps35GtRRK261BygVps35TgAPPSWE2576Kha0Vps35GtRRK261BygVps35TgAPPSWE2576Kha
• abnormal excitatory postsynaptic potential_Vps35<Gt(RRK261)Byg>/Vps35<+>,Tg(APPSWE)2576Kha/0
  http://metadb.riken.jp/0002912I129P2OlaHsdC57BL6SJLVps35GtRRK261BygVps35TgAPPSWE2576Kha0Vps35GtRRK261BygVps35TgAPPSWE2576Kha
• embryonic lethality, complete penetrance_Vps35<Gt(RRK261)Byg>/Vps35<Gt(RRK261)Byg>
  http://metadb.riken.jp/0011092B6129P2Vps35GtRRK261BygVps35GtRRK261BygVps35GtRRK261BygVps35GtRRK261Byg
• reduced NMDA-mediated synaptic currents_Vps35<Gt(RRK261)Byg>/Vps35<+>,Tg(APPSWE)2576Kha/0
  http://metadb.riken.jp/0001902I129P2OlaHsdC57BL6SJLVps35GtRRK261BygVps35TgAPPSWE2576Kha0Vps35GtRRK261BygVps35TgAPPSWE2576Kha
• impaired synaptic plasticity_Vps35<Gt(RRK261)Byg>/Vps35<+>,Tg(APPSWE)2576Kha/0
  http://metadb.riken.jp/0001900I129P2OlaHsdC57BL6SJLVps35GtRRK261BygVps35TgAPPSWE2576Kha0Vps35GtRRK261BygVps35TgAPPSWE2576Kha
• reduced long term potentiation_Vps35<Gt(RRK261)Byg>/Vps35<+>,Tg(APPSWE)2576Kha/0
  http://metadb.riken.jp/0001473I129P2OlaHsdC57BL6SJLVps35GtRRK261BygVps35TgAPPSWE2576Kha0Vps35GtRRK261BygVps35TgAPPSWE2576Kha
• abnormal spatial learning_Vps35<Gt(RRK261)Byg>/Vps35<+>,Tg(APPSWE)2576Kha/0
  http://metadb.riken.jp/0001463I129P2OlaHsdC57BL6SJLVps35GtRRK261BygVps35TgAPPSWE2576Kha0Vps35GtRRK261BygVps35TgAPPSWE2576Kha
• decreased post-tetanic potentiation_Vps35<Gt(RRK261)Byg>/Vps35<+>,Tg(APPSWE)2576Kha/0
  http://metadb.riken.jp/0002922I129P2OlaHsdC57BL6SJLVps35GtRRK261BygVps35TgAPPSWE2576Kha0Vps35GtRRK261BygVps35TgAPPSWE2576Kha