abnormal pancreas morphology_Kras<tm4Tyj>/Kras<+>,Pdpk1<tm1Mlw>/Pdpk1<tm1Mlw>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

http://metadb.riken.jp/0001944I129S4SvJaeKrastm4TyjKrasPdpk1tm1MlwPdpk1tm1MlwPtf1atm1creHnakPtf1aPdpk1tm1MlwKrasKrastm4TyjPtf1aPtf1atm1creHnak

abnormal pancreas morphology_Kras<tm4Tyj>/Kras<+>,Pdpk1<tm1Mlw>/Pdpk1<tm1Mlw>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• pancreas specific transcription factor, 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328312
• 3-phosphoinositide dependent protein kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1338068

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Pdpk1<tm1Mlw>/Pdpk1<tm1Mlw>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pdpk1<tm1Mlw>|Kras<+>|Kras<tm4Tyj>|Ptf1a<+>|Ptf1a<tm1(cre)Hnak>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal pancreas morphology
  http://purl.obolibrary.org/obo/MP_0001944

文献

http://purl.org/net/cito/citesAsAuthority

• Stefan. Eser, et.al., Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer., Cancer cell, 2013, 23
  http://rdf.ncbi.nlm.nih.gov/pubmed/23453624