Stefan. Eser, et.al., Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer., Cancer cell, 2013, 23

http://rdf.ncbi.nlm.nih.gov/pubmed/23453624

Stefan. Eser, et.al., Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer., Cancer cell, 2013, 23

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5510667

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5510667

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• pancreatic acinar-to-ductal metaplasia_Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa>/Gt(ROSA)26Sor<+>,Tg(Ela1-cre/ERT)1Dam/0
  http://metadb.riken.jp/0013221I129S6SvEvTacGtROSA26Sortm2Pik3caDsaGtROSA26SorTgEla1creERT1Dam0GtROSA26Sortm2Pik3caDsaGtROSA26SorTgEla1creERT1Dam
• increased pancreatic intraepithelial neoplasia incidence_Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa>/Gt(ROSA)26Sor<+>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0009152I129S6SvEvTacGtROSA26Sortm2Pik3caDsaGtROSA26SorPtf1atm1creHnakPtf1aPtf1atm1creHnakPtf1aGtROSA26Sortm2Pik3caDsaGtROSA26Sor
• enlarged pancreas_Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa>/Gt(ROSA)26Sor<+>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0003450I129S6SvEvTacGtROSA26Sortm2Pik3caDsaGtROSA26SorPtf1atm1creHnakPtf1aPtf1atm1creHnakPtf1aGtROSA26Sortm2Pik3caDsaGtROSA26Sor
• increased pancreatic ductal adenocarcinoma incidence_Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa>/Gt(ROSA)26Sor<+>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0009151I129S6SvEvTacGtROSA26Sortm2Pik3caDsaGtROSA26SorPtf1atm1creHnakPtf1aPtf1atm1creHnakPtf1aGtROSA26Sortm2Pik3caDsaGtROSA26Sor
• increased pancreatic ductal adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Raf1<tm2Bacc>/Raf1<tm2Bacc>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0009151I129P2OlaHsd129S4SvJaeKrastm4TyjKrasRaf1tm2BaccRaf1tm2BaccPtf1atm1creHnakPtf1aPtf1atm1creHnakPtf1aRaf1tm2BaccKrastm4TyjKras
• increased pancreatic ductal adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm2Tyj>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0009151I129P2OlaHsd129S4SvJaeKrastm4TyjKrasTrp53tm1BrnTrp53tm2TyjPtf1atm1creHnakPtf1aTrp53tm2TyjPtf1atm1creHnakKrasKrastm4TyjTrp53tm1BrnPtf1a
• increased lung non-small cell carcinoma incidence_Kras<tm4Tyj>/Kras<+>,Pdpk1<tm1Mlw>/Pdpk1<tm1Mlw>,Tg(Ela1-cre/ERT)1Dam/0
  http://metadb.riken.jp/0008716I129S4SvJaeKrastm4TyjKrasPdpk1tm1MlwPdpk1tm1MlwTgEla1creERT1Dam0TgEla1creERT1DamPdpk1tm1MlwKrasKrastm4Tyj
• increased carcinoma incidence_Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa>/Gt(ROSA)26Sor<+>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0002038I129S6SvEvTacGtROSA26Sortm2Pik3caDsaGtROSA26SorPtf1atm1creHnakPtf1aPtf1atm1creHnakPtf1aGtROSA26Sortm2Pik3caDsaGtROSA26Sor
• pancreatic acinar-to-ductal metaplasia_Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa>/Gt(ROSA)26Sor<+>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0013221I129S6SvEvTacGtROSA26Sortm2Pik3caDsaGtROSA26SorPtf1atm1creHnakPtf1aPtf1atm1creHnakPtf1aGtROSA26Sortm2Pik3caDsaGtROSA26Sor
• increased pancreatic intraepithelial neoplasia incidence_Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa>/Gt(ROSA)26Sor<+>,Tg(Ela1-cre/ERT)1Dam/0
  http://metadb.riken.jp/0009152I129S6SvEvTacGtROSA26Sortm2Pik3caDsaGtROSA26SorTgEla1creERT1Dam0GtROSA26Sortm2Pik3caDsaGtROSA26SorTgEla1creERT1Dam
• increased pancreas tumor incidence_Kras<tm4Tyj>/Kras<+>,Tg(Ela1-cre/ERT)1Dam/0
  http://metadb.riken.jp/0009153I129S4SvJaeKrastm4TyjKrasTgEla1creERT1Dam0TgEla1creERT1DamKrastm4TyjKras
• increased lung non-small cell carcinoma incidence_Kras<tm4Tyj>/Kras<+>,Tg(Ela1-cre/ERT)1Dam/0
  http://metadb.riken.jp/0008716I129S4SvJaeKrastm4TyjKrasTgEla1creERT1Dam0TgEla1creERT1DamKrastm4TyjKras
• increased pancreas weight_Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa>/Gt(ROSA)26Sor<+>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0009108I129S6SvEvTacGtROSA26Sortm2Pik3caDsaGtROSA26SorPtf1atm1creHnakPtf1aPtf1atm1creHnakPtf1aGtROSA26Sortm2Pik3caDsaGtROSA26Sor
• abnormal pancreas morphology_Kras<tm4Tyj>/Kras<+>,Pdpk1<tm1Mlw>/Pdpk1<tm1Mlw>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>
  http://metadb.riken.jp/0001944I129S4SvJaeKrastm4TyjKrasPdpk1tm1MlwPdpk1tm1MlwPtf1atm1creHnakPtf1aPdpk1tm1MlwKrasKrastm4TyjPtf1aPtf1atm1creHnak