increased cellular sensitivity to gamma-irradiation_Cops6<Gt(RRI087)Byg>/Cops6<+>

http://metadb.riken.jp/0002007I129P2OlaHsdC57BL6JCops6GtRRI087BygCops6Cops6GtRRI087BygCops6

increased cellular sensitivity to gamma-irradiation_Cops6<Gt(RRI087)Byg>/Cops6<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• COP9 signalosome subunit 6
  http://metadb.riken.jp/db/mgi_rdf/MGI:1349439

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cops6<Gt(RRI087)Byg>/Cops6<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cops6<Gt(RRI087)Byg>|Cops6<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased cellular sensitivity to gamma-irradiation
  http://purl.obolibrary.org/obo/MP_0002007

文献

http://purl.org/net/cito/citesAsAuthority

• Ruiying. Zhao, et.al., Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers., The Journal of clinical investigation, 2011, 121
  http://rdf.ncbi.nlm.nih.gov/pubmed/21317535