Ruiying. Zhao, et.al., Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers., The Journal of clinical investigation, 2011, 121

http://rdf.ncbi.nlm.nih.gov/pubmed/21317535

Ruiying. Zhao, et.al., Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers., The Journal of clinical investigation, 2011, 121

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased mortality induced by gamma-irradiation_Cops6<Gt(RRI087)Byg>/Cops6<+>
  http://metadb.riken.jp/0001658I129P2OlaHsdC57BL6JCops6GtRRI087BygCops6Cops6GtRRI087BygCops6
• embryonic growth retardation_Cops6<Gt(RRI087)Byg>/Cops6<Gt(RRI087)Byg>,Trp53<tm1Glo>/Trp53<tm1Glo>
  http://metadb.riken.jp/0003984I129P2OlaHsd129S7SvEvBrdC57BL6JCops6GtRRI087BygCops6GtRRI087BygTrp53tm1GloTrp53tm1GloTrp53tm1GloCops6GtRRI087Byg
• embryonic lethality during organogenesis, complete penetrance_Cops6<Gt(RRI087)Byg>/Cops6<Gt(RRI087)Byg>
  http://metadb.riken.jp/0011098I129P2OlaHsdC57BL6JCops6GtRRI087BygCops6GtRRI087BygCops6GtRRI087Byg
• increased sensitivity to induced cell death_Cops6<Gt(RRI087)Byg>/Cops6<+>
  http://metadb.riken.jp/0008943I129P2OlaHsdC57BL6JCops6GtRRI087BygCops6Cops6GtRRI087BygCops6
• embryonic lethality between somite formation and embryo turning, incomplete penetrance_Cops6<Gt(RRI087)Byg>/Cops6<Gt(RRI087)Byg>
  http://metadb.riken.jp/0011107I129P2OlaHsdC57BL6JCops6GtRRI087BygCops6GtRRI087BygCops6GtRRI087Byg
• decreased embryo size_Cops6<Gt(RRI087)Byg>/Cops6<Gt(RRI087)Byg>,Trp53<tm1Glo>/Trp53<tm1Glo>
  http://metadb.riken.jp/0001698I129P2OlaHsd129S7SvEvBrdC57BL6JCops6GtRRI087BygCops6GtRRI087BygTrp53tm1GloTrp53tm1GloTrp53tm1GloCops6GtRRI087Byg
• decreased thymocyte apoptosis_Trp53<tm1Glo>/Trp53<tm1Glo>
  http://metadb.riken.jp/0009542I129S7SvEvBrdC57BL6JTrp53tm1GloTrp53tm1GloTrp53tm1Glo
• increased incidence of tumors by ionizing radiation induction_Trp53<tm1Glo>/Trp53<+>
  http://metadb.riken.jp/0004500I129S7SvEvBrdC57BL6JTrp53tm1GloTrp53Trp53tm1GloTrp53
• decreased incidence of tumors by ionizing radiation induction_Cops6<Gt(RRI087)Byg>/Cops6<+>
  http://metadb.riken.jp/0004503I129P2OlaHsdC57BL6JCops6GtRRI087BygCops6Cops6GtRRI087BygCops6
• increased cellular sensitivity to gamma-irradiation_Cops6<Gt(RRI087)Byg>/Cops6<+>
  http://metadb.riken.jp/0002007I129P2OlaHsdC57BL6JCops6GtRRI087BygCops6Cops6GtRRI087BygCops6
• increased incidence of tumors by ionizing radiation induction_Cops6<Gt(RRI087)Byg>/Cops6<+>,Trp53<tm1Glo>/Trp53<+>
  http://metadb.riken.jp/0004500I129P2OlaHsd129S7SvEvBrdC57BL6JCops6GtRRI087BygCops6Trp53tm1GloTrp53Trp53tm1GloCops6GtRRI087BygTrp53Cops6
• embryonic lethality during organogenesis, complete penetrance_Cops6<Gt(RRI087)Byg>/Cops6<Gt(RRI087)Byg>
  http://metadb.riken.jp/0011098I129P2OlaHsd129S7SvEvBrdC57BL6JCops6GtRRI087BygCops6GtRRI087BygCops6GtRRI087Byg
• increased thymocyte apoptosis_Cops6<Gt(RRI087)Byg>/Cops6<+>
  http://metadb.riken.jp/0009541I129P2OlaHsdC57BL6JCops6GtRRI087BygCops6Cops6GtRRI087BygCops6
• prenatal lethality, complete penetrance_Cops6<Gt(RRI087)Byg>/Cops6<Gt(RRI087)Byg>,Trp53<tm1Glo>/Trp53<tm1Glo>
  http://metadb.riken.jp/0011091I129P2OlaHsd129S7SvEvBrdC57BL6JCops6GtRRI087BygCops6GtRRI087BygTrp53tm1GloTrp53tm1GloTrp53tm1GloCops6GtRRI087Byg