increased papilloma incidence_Kras<tm4Tyj>/Kras<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Krt1-15-cre/PGR)22Cot/0

http://metadb.riken.jp/0002014I129S4SvJae129S6SvEvTacC57BL6C57BL6JSJLJKrastm4TyjKrasSmad4tm21CxdSmad4tm21CxdTgKrt115crePGR22Cot0Smad4tm21CxdTgKrt115crePGR22CotKrastm4TyjKras

increased papilloma incidence_Kras<tm4Tyj>/Kras<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Krt1-15-cre/PGR)22Cot/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 22, George Cotsarelis
  http://metadb.riken.jp/db/mgi_rdf/MGI:3511784
• SMAD family member 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:894293
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Krt1-15-cre/PGR)22Cot/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Smad4<tm2.1Cxd>|Tg(Krt1-15-cre/PGR)22Cot|Kras<tm4Tyj>|Kras<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased papilloma incidence
  http://purl.obolibrary.org/obo/MP_0002014

文献

http://purl.org/net/cito/citesAsAuthority

• Ruth A. White, et.al., Epithelial stem cell mutations that promote squamous cell carcinoma metastasis., The Journal of clinical investigation, 2013, 123
  http://rdf.ncbi.nlm.nih.gov/pubmed/23999427