Ruth A. White, et.al., Epithelial stem cell mutations that promote squamous cell carcinoma metastasis., The Journal of clinical investigation, 2013, 123

http://rdf.ncbi.nlm.nih.gov/pubmed/23999427

Ruth A. White, et.al., Epithelial stem cell mutations that promote squamous cell carcinoma metastasis., The Journal of clinical investigation, 2013, 123

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased trichoepithelioma incidence_Kras<tm4Tyj>/Kras<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0002732I129S4SvJae129S6SvEvTacC57BL6C57BL6JSJLJKrastm4TyjKrasSmad4tm21CxdSmad4tm21CxdTgKrt115crePGR22Cot0Smad4tm21CxdTgKrt115crePGR22CotKrastm4TyjKras
• increased metastatic potential_Kras<tm4Tyj>/Kras<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0001272I129S4SvJae129S6SvEvTacC57BL6C57BL6JSJLJKrastm4TyjKrasSmad4tm21CxdSmad4tm21CxdTgKrt115crePGR22Cot0Smad4tm21CxdTgKrt115crePGR22CotKrastm4TyjKras
• increased skin squamous cell carcinoma incidence_Kras<tm4Tyj>/Kras<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0009704I129S4SvJae129S6SvEvTacC57BL6C57BL6JSJLJKrastm4TyjKrasSmad4tm21CxdSmad4tm21CxdTgKrt115crePGR22Cot0Smad4tm21CxdTgKrt115crePGR22CotKrastm4TyjKras
• increased skin tumor incidence_Kras<tm4Tyj>/Kras<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0010300I129S4SvJae129S6SvEvTacC57BL6C57BL6JSJLJKrastm4TyjKrasSmad4tm21CxdSmad4tm21CxdTgKrt115crePGR22Cot0Smad4tm21CxdTgKrt115crePGR22CotKrastm4TyjKras
• increased papilloma incidence_Kras<tm4Tyj>/Kras<+>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0002014I129S4SvJaeC57BL6C57BL6JSJLJKrastm4TyjKrasTgKrt115crePGR22Cot0Krastm4TyjTgKrt115crePGR22CotKras
• hair follicle degeneration_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0003413I129S6SvEvTacC57BL6C57BL6JSJLJSmad4tm21CxdSmad4tm21CxdTgKrt115crePGR22Cot0TgKrt115crePGR22CotSmad4tm21Cxd
• enlarged sebaceous gland_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0000652I129S6SvEvTacC57BL6C57BL6JSJLJSmad4tm21CxdSmad4tm21CxdTgKrt115crePGR22Cot0TgKrt115crePGR22CotSmad4tm21Cxd
• abnormal hair growth_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0002073I129S6SvEvTacC57BL6C57BL6JSJLJSmad4tm21CxdSmad4tm21CxdTgKrt115crePGR22Cot0TgKrt115crePGR22CotSmad4tm21Cxd
• increased papilloma incidence_Kras<tm4Tyj>/Kras<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0002014I129S4SvJae129S6SvEvTacC57BL6C57BL6JSJLJKrastm4TyjKrasSmad4tm21CxdSmad4tm21CxdTgKrt115crePGR22Cot0Smad4tm21CxdTgKrt115crePGR22CotKrastm4TyjKras
• increased adenoma incidence_Kras<tm4Tyj>/Kras<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0010383I129S4SvJae129S6SvEvTacC57BL6C57BL6JSJLJKrastm4TyjKrasSmad4tm21CxdSmad4tm21CxdTgKrt115crePGR22Cot0Smad4tm21CxdTgKrt115crePGR22CotKrastm4TyjKras