increased tumor incidence_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Bmi1<tm1(cre/ERT)Mrc>/Bmi1<+>

http://metadb.riken.jp/0002020I129S1Sv129X1SvJC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorBmi1tm1creERTMrcBmi1Bmi1tm1creERTMrcGtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorBmi1

increased tumor incidence_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Bmi1<tm1(cre/ERT)Mrc>/Bmi1<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Bmi1 polycomb ring finger oncogene
  http://metadb.riken.jp/db/mgi_rdf/MGI:88174
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Bmi1<tm1(cre/ERT)Mrc>/Bmi1<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Bmi1<tm1(cre/ERT)Mrc>|Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>|Gt(ROSA)26Sor<+>|Bmi1<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased tumor incidence
  http://purl.obolibrary.org/obo/MP_0002020

文献

http://purl.org/net/cito/citesAsAuthority

• Krystal M. Straessler, et.al., Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics., Cancer cell, 2013, 23
  http://rdf.ncbi.nlm.nih.gov/pubmed/23410975