Krystal M. Straessler, et.al., Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics., Cancer cell, 2013, 23

http://rdf.ncbi.nlm.nih.gov/pubmed/23410975

Krystal M. Straessler, et.al., Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics., Cancer cell, 2013, 23

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5495288

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased tumor incidence_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>
  http://metadb.riken.jp/0002020I129S1Sv129X1SvJC57BL6GtROSA26Sortm1creERTNatGtROSA26Sortm4EWSR1ATF1MrcGtROSA26Sortm1creERTNatGtROSA26Sortm4EWSR1ATF1Mrc
• increased tumor growth/size_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003721IC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorGtROSA26Sortm4EWSR1ATF1MrcGtROSA26Sor
• increased tumor incidence_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Tg(Prrx1-cre/ERT2)1Mlgn/?
  http://metadb.riken.jp/0002020IC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorTgPrrx1creERT21MlgnGtROSA26SorTgPrrx1creERT21MlgnGtROSA26Sortm4EWSR1ATF1Mrc
• lethality throughout fetal growth and development, complete penetrance_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Tg(Prrx1-cre)1Cjt/?
  http://metadb.riken.jp/0011099IC57BL6SJLGtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorTgPrrx1cre1CjtGtROSA26SorGtROSA26Sortm4EWSR1ATF1MrcTgPrrx1cre1Cjt
• abnormal craniofacial morphology_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Pax7<tm1(cre)Mrc>/Pax7<+>
  http://metadb.riken.jp/0000428I129S1Sv129X1SvJC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorPax7tm1creMrcPax7GtROSA26Sortm4EWSR1ATF1MrcPax7tm1creMrcPax7GtROSA26Sor
• decreased body size_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Myf5<tm1(cre)Mrc>/Myf5<+>
  http://metadb.riken.jp/0001265I129S1Sv129X1SvJC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorMyf5tm1creMrcMyf5Myf5Myf5tm1creMrcGtROSA26SorGtROSA26Sortm4EWSR1ATF1Mrc
• myopathy_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Pax7<tm1(cre/ERT2)Gaka>/Pax7<+>
  http://metadb.riken.jp/0000751I129S6SvEvTacC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorPax7tm1creERT2GakaPax7GtROSA26SorPax7GtROSA26Sortm4EWSR1ATF1MrcPax7tm1creERT2Gaka
• decreased litter size_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>
  http://metadb.riken.jp/0001935I129S1Sv129X1SvJC57BL6GtROSA26Sortm1creERTNatGtROSA26Sortm4EWSR1ATF1MrcGtROSA26Sortm1creERTNatGtROSA26Sortm4EWSR1ATF1Mrc
• embryonic lethality, complete penetrance_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Tg(Wnt1-cre)11Rth/?
  http://metadb.riken.jp/0011092IC57BL6JCBAJGtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorTgWnt1cre11RthGtROSA26SorTgWnt1cre11RthGtROSA26Sortm4EWSR1ATF1Mrc
• abnormal tumor latency_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010307IC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorGtROSA26Sortm4EWSR1ATF1MrcGtROSA26Sor
• embryonic lethality, complete penetrance_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Tg(Tek-cre)1Ywa/?
  http://metadb.riken.jp/0011092IC57BL6SJLGtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorTgTekcre1YwaGtROSA26Sortm4EWSR1ATF1MrcTgTekcre1YwaGtROSA26Sor
• increased tumor incidence_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Bmi1<tm1(cre/ERT)Mrc>/Bmi1<+>
  http://metadb.riken.jp/0002020I129S1Sv129X1SvJC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorBmi1tm1creERTMrcBmi1Bmi1tm1creERTMrcGtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorBmi1
• increased tumor latency_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>
  http://metadb.riken.jp/0009828I129S1Sv129X1SvJC57BL6GtROSA26Sortm1creERTNatGtROSA26Sortm4EWSR1ATF1MrcGtROSA26Sortm1creERTNatGtROSA26Sortm4EWSR1ATF1Mrc
• abnormal limb morphology_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Tg(Prrx1-cre)1Cjt/?
  http://metadb.riken.jp/0002109IC57BL6SJLGtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorTgPrrx1cre1CjtGtROSA26SorGtROSA26Sortm4EWSR1ATF1MrcTgPrrx1cre1Cjt
• increased incidence of tumors by chemical induction_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0004499IC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorGtROSA26Sortm4EWSR1ATF1MrcGtROSA26Sor
• premature death_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Myf5<tm1(cre)Mrc>/Myf5<+>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorMyf5tm1creMrcMyf5Myf5Myf5tm1creMrcGtROSA26SorGtROSA26Sortm4EWSR1ATF1Mrc
• myopathy_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Myf5<tm1(cre)Mrc>/Myf5<+>
  http://metadb.riken.jp/0000751I129S1Sv129X1SvJC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorMyf5tm1creMrcMyf5Myf5Myf5tm1creMrcGtROSA26SorGtROSA26Sortm4EWSR1ATF1Mrc
• embryonic lethality, complete penetrance_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0011092IC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorPax3tm1creJoePax3Pax3GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorPax3tm1creJoe
• premature death_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6GtROSA26Sortm1creERTNatGtROSA26Sortm4EWSR1ATF1MrcGtROSA26Sortm1creERTNatGtROSA26Sortm4EWSR1ATF1Mrc
• postnatal growth retardation_Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>
  http://metadb.riken.jp/0001732I129S1Sv129X1SvJC57BL6GtROSA26Sortm1creERTNatGtROSA26Sortm4EWSR1ATF1MrcGtROSA26Sortm1creERTNatGtROSA26Sortm4EWSR1ATF1Mrc
• lethality throughout fetal growth and development, complete penetrance_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Pax7<tm1(cre)Mrc>/Pax7<+>
  http://metadb.riken.jp/0011099I129S1Sv129X1SvJC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorPax7tm1creMrcPax7GtROSA26Sortm4EWSR1ATF1MrcPax7tm1creMrcPax7GtROSA26Sor
• abnormal tumor morphology_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003448IC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorGtROSA26Sortm4EWSR1ATF1MrcGtROSA26Sor
• myopathy_Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>/Gt(ROSA)26Sor<+>,Tg(Prrx1-cre/ERT2)1Mlgn/?
  http://metadb.riken.jp/0000751IC57BL6GtROSA26Sortm4EWSR1ATF1MrcGtROSA26SorTgPrrx1creERT21MlgnGtROSA26SorTgPrrx1creERT21MlgnGtROSA26Sortm4EWSR1ATF1Mrc

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5495288