increased B cell derived lymphoma incidence_H2afx<tm1Fwa>/H2afx<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>

http://metadb.riken.jp/0002023I129S6SvEvTac129S7SvEvBrdC57BL6H2afxtm1FwaH2afxtm1FwaTrp53tm1BrdTrp53tm1BrdTrp53tm1BrdH2afxtm1Fwa

increased B cell derived lymphoma incidence_H2afx<tm1Fwa>/H2afx<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• H2A histone family, member X
  http://metadb.riken.jp/db/mgi_rdf/MGI:102688

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• H2afx<tm1Fwa>/H2afx<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brd>|H2afx<tm1Fwa>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased B cell derived lymphoma incidence
  http://purl.obolibrary.org/obo/MP_0002023

文献

http://purl.org/net/cito/citesAsAuthority

• Craig H. Bassing, et.al., Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors., Cell, 2003, 114
  http://rdf.ncbi.nlm.nih.gov/pubmed/12914700