increased T cell derived lymphoma incidence_Grb2<tm1Paw>/Grb2<+>,Pten<tm2Mak>/Pten<tm2Mak>,Tg(Lck-cre)548Jxm/0

http://metadb.riken.jp/0002024I129P2OlaHsdC57BL6CBAGrb2tm1PawGrb2Ptentm2MakPtentm2MakTgLckcre548Jxm0Ptentm2MakTgLckcre548JxmGrb2tm1PawGrb2

increased T cell derived lymphoma incidence_Grb2<tm1Paw>/Grb2<+>,Pten<tm2Mak>/Pten<tm2Mak>,Tg(Lck-cre)548Jxm/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• transgene insertion 548, Jamey Marth
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176198
• growth factor receptor bound protein 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:95805

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Grb2<tm1Paw>/Grb2<+>,Pten<tm2Mak>/Pten<tm2Mak>,Tg(Lck-cre)548Jxm/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pten<tm2Mak>|Tg(Lck-cre)548Jxm|Grb2<tm1Paw>|Grb2<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased T cell derived lymphoma incidence
  http://purl.obolibrary.org/obo/MP_0002024

文献

http://purl.org/net/cito/citesAsAuthority

• Megan. Cully, et.al., grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice., Proceedings of the National Academy of Sciences of the United States of America, 2004, 101
  http://rdf.ncbi.nlm.nih.gov/pubmed/15492213